Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 28, 2013; 19(40): 6888-6893
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6888
Table 1 Genotype and allele distributions of interleukin-6 tag single nucleotide polymorphisms in patients with chronic hepatitis B virus infection and those with self- limiting hepatitis B virus infection n (%)
IL-6 SNP siteChronic HBV infectionSelf-limiting HBV infectionP valueOR (95%CI)
rs17147230n = 501n = 301
AA155 (0.309)85 (0.282)1.0
AT241 (0.481)155 (0.515)0.3480.853 (0.611-1.189)
TT105 (0.210)61 (0.203)0.7840.944 (0.625-1.425)
A551 (0.550)325 (0.540)0.6961.041 (0.850-1.276)
T451 (0.450)277 (0.460)
rs2066992
GG45 (0.090)20 (0.066)1.0
GT190 (0.379)118 (0.392)0.2520.716 (0.403-1.271)
TT266 (0.531)163 (0.542)0.2610.725 (0.414-1.272)
G280 (0.279)158 (0.262)0.4601.090 (0.868-1.369)
T722 (0.721)444 (0.738)
rs2069837
AA331 (0.661)202 (0.671)1.0
AG151 (0.301)86 (0.286)0.6701.072 (0.780-1.472)
GG19 (0.038)13 (0.043)0.7580.892 (0.431-1.845)
A813 (0.811)490 (0.814)0.8980.983 (0.759-1.274)
G189 (0.189)112 (0.186)
rs2069852
AA208 (0.415)138 (0.458)1.0
AG229 (0.457)132 (0.439)0.3641.151 (0.850-1.559)
GG64 (0.128)31 (0.103)0.1981.370 (0.848-2.213)
A645 (0.644)408 (0.678)0.1650.859 (0.693-1.064)
G357 (0.356)194 (0.322)
Table 2 Distribution of haplotypes of interleukin-6 tag single nucleotide polymorphisms in patients with chronic hepatitis B virus infection and those with self-limiting hepatitis B virus infection
HaplotypesFrequency (cases)Frequency (controls)χ2P valueOR (95%CI)
ATAA526.10 (0.525)306.81 (0.510)0.2670.60511.056 (0.860-1.297)
TGAG89.34 (0.089)45.98 (0.076)0.7530.38541.179 (0.813-1.709)
TGGG172.46 (0.172)96.25 (0.160)0.3580.54941.087 (0.827-1.429)
TTAA117.81 (0.118)101.19 (0.168)8.3800.00380.655 (0.491-0.873)
TTAG70.30 (0.070)33.8 (0.056)1.2370.26601.272 (0.832-1.944)