Endoscopic ultrasound elastography for differentiating between pancreatic adenocarcinoma and inflammatory masses: A meta-analysis

Table 1 Baseline characteristics of the studies in the analysis

Ref.	Type of publication	Design of study	Diagnostic standard	Cut-off	No.
Săftoiu et al[7]	Full text	Single center	Hue histogram	> 175	54
Iglesias-Garcia et al[8]	Full text	Single center	Color pattern	Blue-predominant	76
Janssen et al[9]	Full text	Single center	Color pattern	Blue-predominant	25
Deprez et al[10]	Abstract	Single center	Color pattern	Blue-predominant	13
Săftoiu et al[11]	Full text	Single center	Hue histogram	> 175	43
Iglesias-Garcia et al[12]	Full text	Single center	Color pattern	Blue-predominant	119
Giovannini et al[13]	Full text	Multicenter	Color pattern	Blue-predominant	96
Giovannini et al[14]	Full text	Single center	Color pattern	Blue-predominant	18
Itokawa et al[24]	Full text	Single center	Color pattern	Blue-predominant	79
Săftoiu et al[34]	Full text	Multicenter	Color pattern	> 175	258

Table 2 Meta-regression analysis for the potential source of heterogeneity

Study characteristics	Z	P value	95%CI
Diagnostic standard (color pattern vs hue histogram)	2.90	0.00	0.68-3.50
Blind (yes vs unclear)	1.36	0.17	-0.87-4.82
Sample size (≥ 50 vs < 50)	0.13	0.90	-1.90-2.17
Type of publication (full text vs abstract)	1.28	0.20	-1.33-6.37
Design of study (single center vs multicenter)	0.04	0.97	-1.35-1.40

Table 3 Subgroup analysis on the basis of the diagnostic standards

Pooled estimate	Color pattern (n = 426)1		Hue histogram (n = 355)2
	Pooled result (95%CI)	I2	Pooled result (95%CI)	I2
Sensitivity	0.99 (0.97-1.00)	0.00%	0.92 (0.89-0.95)	20.10%
Specificity	0.76 (0.67-0.83)	0.00%	0.68 (0.57-0.78)	0.00%
Positive LR	3.36 (2.39-4.72)	17.90%	2.84 (2.05-3.93)	0.00%
Negative LR	0.03 (0.01-0.07)	0.00%	0.12 (0.08-0.19)	0.00%
Diagnostic OR	129.96 (47.02-359.16)	0.00%	24.69 (12.81-47.59)	0.00%

¹Studies using the color pattern as the diagnostic standard and the total number of patients involved;

²Studies using the hue histogram as the diagnostic standard and the total number of patients involved. OR: Odds ratio; LR: Likelihood ratio.