Connective tissue diseases in primary biliary cirrhosis: A population-based cohort study

doi:10.3748/wjg.v19.i31.5131

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 19, Issue 31

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7123)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

439

HTML

4148

Figures (1-1)

166

Tables (1-3)

179

Sum=4932

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1219

Download

972

Sum=2191

Aug 21, 2013 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (51)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Aug 21, 2013; 19(31): 5131-5137
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5131

Table 1 Baseline characteristics of the study population

Characteristic	Cohort representation
Sex, female/male	294/28
Age (yr)	53 ± 12
Duration of disease (yr)	5.8 ± 3.5
Mayo risk score	4.5 ± 1.1
Positive ANA	275/316 (87.0)
Positive AMA	290/319 (90.9)
Positive AMA-M₂	262/290 (90.3)
Titers of AMA-M₂ (IU/mL)	139.6 ± 107.9
Liver biopsy	72 (22.4)

Data are presented as mean ± SD, ratio or n (%). ANA: Anti-nuclear antibody; AMA: Anti-mitochondrial antibody; AMA-M₂: M₂ subtype of anti-mitochondrial antibody.

Table 2 Inter-study comparison of patterns of connective tissue diseases in primary biliary cirrhosis patients n (%)

	Wang et alChina	*Watt et al[16]United Kingdom*	*Marasini et al[17]Italy*
PBC	322	160	170
CTDs in PBC	150 (46.6)	84 (53.0)	62 (36.5)
PBC + SS	121 (37.6)	40 (25.0)^a	6 (3.5)^a
PBC + SSc	9 (2.8)	12 (8.0)^a	21 (12.3)^a
PBC + SLE	12 (3.7)	2 (1.3)	3 (1.8)
PBC + RA	9 (2.8)	27 (17.0)^a	3 (1.8)
PBC + PM	10 (3.1)	0 (0.0)	1 (0.6)
PBC + MCTD	0 (0.0)	0 (0.0)	1 (0.6)

^aP < 0.05 vs Wang et al (China, the current study). PBC: Primary biliary cirrhosis; CTDs: Connective tissue diseases; SS: Sjögren’s syndrome; SSc: Systemic sclerosis; SLE: Systemic lupus erythematosus; RA: Rheumatoid arthritis; PM: Polymyositis; MCTD: Mixed connective tissue disease.

Table 3 Clinical features and laboratory results of patients with primary biliary cirrhosis alone and patients with primary biliary cirrhosis plus one other connective tissue diseases

	PBC (n =172)	PBC + SS (n =121)	PBC + SSc (n = 9)	PBC + SLE (n =12)	PBC + RA (n = 9)	PBC + PM (n = 10)
Female/male	153/19	112/9	9/0	12/0	7/2	7/3
Age (yr)	53 ± 11	53 ± 12	51 ± 6¹	50 ± 9¹	59 ± 121	53 ± 8¹
Fever	11 (6.4)	19 (15.7)^a	0 (0)	3 (25.0)	1 (11.1)	1 (10.0)
RP	32 (18.6)	23 (19.0)	4 (44.4)	5 (41.7)	0 (0)	0 (0)
Arthralgia	37 (21.5)	31 (25.6)	2 (22.2)	4 (33.3)	9 (100)^a	1 (10)
ILD	13 (7.6)	27 (22.3)^a	3 (33.3)^a	0 (0)	1 (11.1)	2 (20)
PAH	11 (6.4)	13 (10.7)	2 (22.2)	1 (8.3)	0 (0)	0 (0)
Cardiac	5 (2.9)	3 (2.5)	0 (0)	0 (0)	0 (0)	4 (40.0)^a
Renal	9 (5.2)	8 (6.6)	1 (11.1)	4 (33.3)^a	0 (0)	0 (0)
WBC (10⁹/L)	5.7 ± 2.6	5.0 ± 2.9	5.7 ± 2.8¹	4.0 ± 1.1¹^a	5.7 ± 2.4¹	7.9 ± 3.4¹^a
Hb (g/L)	126 ± 20	118 ± 18	120 ± 23¹	102 ± 20¹^a	110 ± 11¹^a	127 ± 16¹
PLT (10⁹/L)	189 ± 82	135 ± 69	190 ± 103	96 ± 75^a	247 ± 142	206 ± 9¹
ALT (U/L)	79 ± 76	91± 75	76 ± 62¹	69 ± 72¹	56 ± 46¹	73 ± 56¹
AST (U/L)	76± 62	90 ± 64	96 ± 41¹	69 ± 55¹	79 ± 52¹	73 ± 33¹
ALP (U/L)	250 ± 221	287 ± 224	291 ± 166¹	173 ± 98¹	487 ± 411¹^a	153 ± 98¹
γ-GT (U/L)	320 ± 340	309 ± 290	344 ± 346¹	207 ± 153¹^a	239 ± 166¹	264 ± 275¹
IgG (g/L)	17.1 ± 6.2	21.0 ± 12.4^a	17.3 ± 5.8¹	15.8 ± 5.2¹	22.2 ± 5.1¹^a	16.4 ± 4.4¹
IgM (g/L)	4.5 ± 4.7	4.3 ± 3.9	3.4 ± 1.8¹	1.9 ± 1.2¹^a	4.2 ± 3.6¹	5.4 ± 3.1¹
ESR (mm/1h)	41 ± 28	57 ± 38^a	47 ± 34¹	47 ± 25¹	76 ± 30¹^a	48 ± 20¹
RF+	31/156 (19.9)	92/120 (76.7)^a	4/8 (50.0)	5/11 (45.5)	9/9 (100)^a	4/10 (40.0)
ANA	142/169 (84.0)	111/119 (93.3)	9/9 (100)	12/12 (100)	8/9 (88.9)	10/10 (100)
AMA	153/171 (89.5)	109/120 (90.8)	8/9 (88.9)	11/12 (91.7)	8/9 (88.9)	10/10 (100)
AMA- M₂ (IU/mL)	147± 125	130 ± 105	119 ± 115¹	160 ± 116¹	139 ± 118¹	172 ± 138¹

Data are presented as mean ± SD, ratio or n (%).

¹Non-normally distributed data compared with PBC patients by the Wilcoxon test.

^aP < 0.05 vs PBC patients. PBC: Primary biliary cirrhosis; SS: Sjögren’s syndrome; SSc: Systemic sclerosis; SLE: Systemic lupus erythematosus; RA: Rheumatoid arthritis; PM: Polymyositis; WBC: White blood cell count; Hb: Hemoglobin; PLT: Platelet count; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; γ-GT: γ-glutamyl transpeptidase; IgG: Immunoglobulin G; IgM: Immunoglobulin M; ESR: Erythrocyte sedimentation rate; RF: Rheumatoid factor; ANA: Anti-nuclear antibody; AMA: Anti-mitochondrial antibody; AMA-M₂: M₂ subtype of anti-mitochondrial antibody.

Citation: Wang L, Zhang FC, Chen H, Zhang X, Xu D, Li YZ, Wang Q, Gao LX, Yang YJ, Kong F, Wang K. Connective tissue diseases in primary biliary cirrhosis: A population-based cohort study. World J Gastroenterol 2013; 19(31): 5131-5137
URL: https://www.wjgnet.com/1007-9327/full/v19/i31/5131.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i31.5131