Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. May 14, 2013; 19(18): 2731-2735
Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2731
Table 1 Possible functional effects and mechanisms of action of cathelicidins in different gastrointestinal disorders
Type of GI disordersFunctional effectsMechanismsRef.
UlcerIncreases of cell proliferation, re-epithelialization and angiogenesisActivation of growth factors and their receptors[11,13-17]
InflammationDecrease of pathogenic microbes, inflammatory cytokines and apoptosis; increase of mucus secretionActivation of MAP kinase, formyl peptide receptor and mucin genes; electrostatic interaction on microbial membrane[1,5,8,23]
CancerInduction of apoptosis and cell cycle arrestRelease of AIF/EndoG; activation of BMPR and Smads[29,30]