Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2731
Revised: March 19, 2013
Accepted: April 3, 2013
Published online: May 14, 2013
Core tip: Cathelicidin is one of the most important host defense peptides known today. It carries multiple and yet unique biological functions against pathogens which contribute to the induction and also progression of infection, inflammation and cancer, the three major types of diseases in mankind. Deficiency of such peptide would cause multiple dysfunctions in the body. In this review we highlight the physiological role and therapeutic potential of cathelicidin in inflammation and cancer and also mucosal repair in the gut. All these information would shed new lights on the development of cathelicidin as therapeutic agent for different disorders in the gastrointestinal tract.