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Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 21, 2013; 19(15): 2313-2318
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2313
Table 1 Case reports of hyposplenism-related infections in patients with celiac disease
Ref.No. of casesType of infectionSupplementary findings
Corazza et al[23]1Pneumoccoccal pneumoniaSplenic atrophy
Matuchansky et al[24]2Pneumococcal pneumonia, infectious pericarditisSplenic atrophy, MLNC
O’Donoghue[25]1Pneumococcal septicemiaSplenic atrophy
Logan et al[26]2Pneumococcal meningitis, septicemia by SalmonellaSplenic atrophy
Stevens et al[27]3Lung abscesses by Staphyloccus and KlebsiellaSplenic atrophy
Howat et al[28]2Fatal chest infection, septicemiaSplenic atrophy, MLNC
Harmon et al[29]1Septicemia by KlebsiellaSplenic atrophy
Table 2 Traditional polysaccharide and new conjugate anti-pneumococcal vaccines used in the prophylactic management of asplenic/hyposplenic patients
VaccineBrand nameStructureMechanismSerotypeIndication
PPV23Pneumovax®PolysaccharideT-cell independent1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33FAsplenic or hyposplenic adults Asplenic or hyposplenic children > 5 yr
PCV13Prevnar®Protein-conjugate (CRM197 protein)T-cell dependent1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23FAsplenic or hyposplenic children < 5 yr
Table 3 Celiac patients in whom splenic function should be assessed
Patients with complications (RCD, UJI, EATL, collagenous sprue)
Patients with concomitant autoimmune disorders
Patients with old age at diagnosis
Patients with previous history of major infections/sepsis and/or thromboembolism
Patients with mesenteric lymph node cavitation and/or splenic atroph