Vaccination with dendritic cells pulsed with hepatitis C pseudo particles induces specific immune responses in mice

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Feb 28, 2012 (publication date) through Apr 16, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Feb 28, 2012; 18(8): 785-793
Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.785

Table 1 Different vaccination groups with 8 mice each

No.	Vaccine	Purpose
1	Sodium chloride	Negative control
2	DC 293T-supernatant, concentrated with Amicon filtration as the HCVpp	Negative control to rule out immunogenic components of Amicon filter and 293T supernatant
3	HCVpp	Immunogenic impact of HCVpp
4	DC activated with HCVpp	Treatment group without adjuvant
5	DC activated with HCVpp + LPS	Treatment group with adjuvant

DC: Dendritic cell; HCVpp: Hepatitis C virus pseudo particles; LPS: Lipopolysaccharide.

Table 2 Amino acid sequence of the E1 and E2 protein of the hepatitis C virus Con1b isolate

E1	192 - 231	GYEVRNVSGVYHVTNDCSNASIVYEAADMIMHTPGCVPCV
aa 192-383	232 - 271	RENNSSRCWVALTPTLAARNASVPTTTIRRHVDLLVGAAA
	272 - 311	LCSAMYVGDLCGSVFLVAQLFTFSPRRHETVQDCNCSIYP
193 aa total	312 - 351	GHVTGHRMAWDMMMNWSPTAALVVSQLLRIPQAVVDMVAG
	352 - 383	AHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDG
E2	384 - 423	GTYVTGGTMAKNTLGITSLFSPGSSQKIQLVNTNGSWHIN
aa 384-746	424 - 463	RTALNCNDSLNTGFLAALFYVHKFNSSGCPERMASCSPID
	464 - 503	AFAQGWGPITYNESHSSDQRPYCWHYAPRPCGIVPAAQVC
363 aa total	504 - 543	GPVYCFTPSPVVVGTTDRFGVPTYSWGENETDVLLLNNTR
	544 - 583	PPQGNWFGCTWMNSTGFTKTCGGPPCNIGGIGNKTLTCPT
	584 - 623	DCFRKHPEATYTKCGSGPWLTPRCLVHYPYRLWHYPCTVN
	624 - 663	FTIFKVRMYVGGVEHRLEAACNWTRGERCNLEDRDRSELS
	664 - 703	PLLLSTTEWQVLPCSFTTLPALSTGLIHLHQNVVDVQYLY
	704 - 743	GIGSAVVSFAIKWEYVLLLFLLLADARVCACLWMMLLIAQ
	744 - 746	AEA

Citation: Weigand K, Voigt F, Encke J, Hoyler B, Stremmel W, Eisenbach C. Vaccination with dendritic cells pulsed with hepatitis C pseudo particles induces specific immune responses in mice. World J Gastroenterol 2012; 18(8): 785-793
URL: https://www.wjgnet.com/1007-9327/full/v18/i8/785.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i8.785