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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 28, 2012; 18(28): 3673-3680
Published online Jul 28, 2012. doi: 10.3748/wjg.v18.i28.3673
Published online Jul 28, 2012. doi: 10.3748/wjg.v18.i28.3673
Age (yr), median (mean ± SD) | 64.0 (63.0 ± 8.1) |
Gender, n (%) | |
Male | 12 (50) |
Female | 12 (50) |
Location, n (%) | |
Left lobe | 16 (67) |
Right lobe | 8 (33) |
Tumor size (cm), median (mean ± SD) | 30 (42.2 ± 26.6) |
Macroscopic findings of bile duct, n (%) | |
Duct-ectatic | 5 (21) |
Cystic | 19 (79) |
Macroscopic mucin hypersecretion, n (%) | |
Present | 19 (79) |
Absent | 5 (21) |
Histological structure pattern, n (%) | |
Papillary | 20 (83) |
Tubular and papillary | 4 (17) |
Histological grade, n (%) | |
Malignant | 16 (67) |
Borderline | 3 (12) |
Adenoma | 5 (21) |
Microinvasion, n (%) | |
Present | 4 (17) |
Absent | 20 (83) |
Case 1 | Case 2 | Case 31 | Case 4 | |
Age (yr) | 77 | 49 | 63 | 52 |
Gender | Male | Female | Male | Male |
Location | Left lobe | |||
Tumor size (cm) | 10 | 2 | 6 | 2.6 |
Mucin produced | Absent | Present | ||
macroscopically | ||||
Macroscopic findings | Duct-ectatic type | Cystic | ||
Histopathological grade | Malignant | Borderline | Adenoma | Adenoma |
Microinvasion | Absent | |||
Mucin immunohistochemistry | ||||
MUC1 | 3+ | - | - | 1+ |
MUC2 | - | - | - | - |
MUC5AC | - | 1+ | - | - |
MUC6 | 3+ | 3+ | + | 3+ |
Malignantn (16.67%) | Borderline n (3.12%)/adenoma n (5.21%) | |
MUC11 | ||
3+ (38%) | 9 (56) | 0 |
2+ (0%) | 0 | 0 |
1+/- (62%) | 7 (44) | 8 (100) |
MUC2 | ||
3+ (13%) | 1 (6) | 2 (25) |
2+ (4%) | 1 (6) | 0 |
1+/- (83%) | 14 (88) | 6 (75) |
MUC5AC | ||
3+ (46%) | 7 (44) | 4 (50) |
2+ (12%) | 2 (12) | 1 (13) |
1+/- (42%) | 7 (44) | 3 (37) |
MUC6 | ||
3+ (46%) | 4 (25) | 5 (63) |
2+ (12%) | 4 (25) | 1 (22) |
1+/- (44%) | 8 (50) | 2 (25) |
Proliferation | ||
Ki-67 (LI, %, mean ± SD)2 | 22.2 ± 15.5 | 7.5 ± 6.3 |
Genetic status | ||
TP53 overexpression | 0 | 0 |
β-catenin nuclear expression (17%)3 | 2 (13) | 0 |
- Citation: Naito Y, Kusano H, Nakashima O, Sadashima E, Hattori S, Taira T, Kawahara A, Okabe Y, Shimamatsu K, Taguchi J, Momosaki S, Irie K, Yamaguchi R, Yokomizo H, Nagamine M, Fukuda S, Sugiyama S, Nishida N, Higaki K, Yoshitomi M, Yasunaga M, Okuda K, Kinoshita H, Nakayama M, Yasumoto M, Akiba J, Kage M, Yano H. Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases. World J Gastroenterol 2012; 18(28): 3673-3680
- URL: https://www.wjgnet.com/1007-9327/full/v18/i28/3673.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i28.3673