Effects of anti-hypertensive drugs on esophageal body contraction

Table 1 Resting LES pressure with and without administration of anti-hypertensive drugs (mean ± SE)

	No medication		Nifedipine		Losartan		Atenolol
	Sitting	Supine	Sitting	Supine	Sitting	Supine	Sitting	Supine
LESP (mmHg)	12.8 ± 2.4	19.8 ± 1.5a	10.2 ± 1.9	16.7 ± 1.7a	12.4 ± 2.7	20.8 ± 2.1a	15.8 ± 2.0	21.8 ± 2.4a

^aSignificantly different in comparison with sitting (P < 0.05). LESP: Lower esophageal sphincter pressure.

Table 2 Peak peristaltic pressure in three segments during esophageal body contractions with and without administration of antihypertensive drugs (mean ± SE)

	No medication		Nifedipine		Losartan		Atenolol
	Sitting	Supine	Sitting	Supine	Sitting	Supine	Sitting	Supine
Segment 1 (mmHg)	45.3 ± 12.9	72.4 ± 14.4	42.1 ± 10.1	77.4 ± 12.6	40.5 ± 10.5	77.5 ± 12.0	42.8 ± 8.2	79.3 ± 12.2
Segment 2 (mmHg)	105.5 ± 10.7	117.0 ± 12.3	83.7 ± 9.7	109.5 ± 15.4	96.4 ± 17.3	120.5 ± 34.9	122.0 ± 15.6	153.8 ± 12.4a
Segment 3 (mmHg)	141.7 ± 15.2	148.9 ± 31.6	115.5 ± 20.6	140.4 ± 9.8	152.2 ± 27.9	181.1 ± 31.9	216.9 ± 39.4a	246.5 ± 45.1a

^aSignificantly different in comparison with no medication (P < 0.05).

Table 3 Velocity of esophageal peristalsis with and without administration of anti-hypertensive drugs (mean ± SE)

	No medication		Nifedipine		Losartan		Atenolol
	Sitting	Supine	Sitting	Supine	Sitting	Supine	Sitting	Supine
Velocity (mm/s)	4.9 ± 0.4	4.6 ± 0.3	5.1 ± 0.4	4.8 ± 0.2	4.8 ± 0.5	4.6 ± 0.4	4.7 ± 0.3	4.4 ± 0.2a

^aSignificantly different in comparison with no medication (P < 0.05).