Original Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Feb 7, 2010; 16(5): 571-577
Published online Feb 7, 2010. doi: 10.3748/wjg.v16.i5.571
Table 1 Expression of CR-1 protein in normal gastric mucosa, chronic atrophic gastritis, intestinal metaplasia, dysplasia and GC
GroupsnCR-1 expression
++++ (%)χ²P
-++++++
Normal mucosa95542311743.28.394/25.813< 0.039a/< 0.001b
CAG40141112365.04.214/4.1920.239c/0.242d
IM4881819383.39.1690.027e
DYS255136180.013.051/4.1350.005f/0.246g
GC1785163382671.321.236/3.347< 0.001h/0.341i
Table 2 Expression of p-STAT3 protein in normal gastric mucosa, chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric carcinoma
Groupsnp-STAT3 expression
++++ (%)χ²P
-++++++
Normal mucosa95562511341.118.4050.012ab/< 0.001c
CAG4016222060.00.113ad/0.003ae
IM4811286377.16.6040.087f
DYS25878268.06.2590.022ag/0.103h
GC1787169231560.110.322/7.2200.016i/0.065j
Table 3 Correlation between CR-1 expression and clinicopathological features of GC
GroupsnCripto-1 expression
++++ (%)χ²P
-++++++
Gender4.0520.269
Female57112414880.7
Male1214039241866.9
Age (yr)2.9200.417
≤ 61902233231275.6
> 61882930151467.0
Borrmann type0.1951
Bor I type40301100
Bor II type22697072.7
Bor III type1404148272470.7
Bor IV type12434166.7
WHO’s histological types< 0.0011
Papillary. ade.20110100
Well-diff. ade.9322266.717.872< 0.0012
Moderately-diff. ade.65828111887.7
Poorly-diff. ade.74272716463.5
Undiff. ade.30120100
Mucinous ade.191133242.1
SRC6213066.7
Lauren’s types28.523< 0.001
Intestinal type741129142068.419.566< 0.0013
Diffused type85293121465.9
Mixed type191133242.1
Lymph node metastasis12.3940.006
No4923149353.1
Yes1292849292378.3
Table 4 Correlation between p-STAT3 expression and clinicopathological features of GC
GroupsnP-STAT3 expression
++++ (%)χ²P
-++++++
Gender3.0910.391
Female5718277568.4
Male1215342161056.2
Age (yr)2.1770.544
≤ 6190373513558.9
> 61883434101061.4
Borrmann type0.9091
Bor I type4120175.0
Bor II type221182161.2
Bor III type1405553201260.7
Bor IV type12461166.7
WHO’s histological types0. 1001
Papillary. ade.20002100
Well-diff. ade.9440155.6
Moderately-diff. ade.65232310964.5
Poorly-diff. ade.7435297352.7
Undiff. ade.3120066.7
Mucinous ade.19784063.2
SRC6132083.3
Lauren’s types11.4170.076
Intestinal type74272691263.5
Diffused type85373510356.5
Mixed type19784063.2
Lymph node metastasis9.6320.021
No4928163242.9
Yes1294353201366.7
Table 5 Relationship between CR-1 and p-STAT3 expression in GC
Cripto-1 expressionp-STAT3 expression
Total
-++++++
-24216051
+28229463
++13173538
+++695626
Total71692315178