FOXP3 expression and clinical characteristics of hepatocellular carcinoma

Table 1 Association of forkhead box protein 3 expression with pathologic grades in 21 hepatocellular carcinoma tissue sections by immunohistochemical n (%)

Demographic or clinical characteristic	No. of tumorspecimens (n = 21)	FOXP3		P	FOXP3 immunohistochemistry intensity score				P
		Positive	Negative		0	1	2	3
Gender
Male	20	10 (50)	10 (50)	1.00001	10 (50)	7 (35)	3 (15)	0 (0)	1.00001
Female	1	0 (0)	1 (100)		1 (100)	0 (0)	0 (0)	0 (0)
Age (yr)
> 60	4	3 (75)	1 (25)	0.31081	1 (25)	1 (25)	2 (50)	0 (0)	0.10311
≤ 60	17	7 (41)	10 (59)		10 (59)	6 (35)	1 (6)	0 (0)
Differentiation grade
Well	7	4 (57)	3 (43)	1.00001	3 (43)	3 (43)	1 (14)	0 (0)	1.00001
Moderate	7	3 (43)	4 (57)		4 (57)	2 (29)	1 (14)	0 (0)
Poor	7	3 (43)	4 (57)		4 (57)	2 (29)	1 (14)	0 (0)
Tumor	21	10 (48)	11 (52)	0.02651a	11 (52)	7 (33)	3 (15)	0 (0)
Normal	8	0 (0)	8 (100)		8 (100)	0 (0)	0 (0)	0 (0)

¹Fisher's exact test.

^aP < 0.05. FOXP3: Forkhead box protein 3.

Table 2 Association of forkhead box protein 3 expression with pathologic grades in 140 hepatocellular carcinoma tissue arrays by immunohistochemical n (%)

Demographic or clinical characteristic	No. of tumorspecimens (n = 140)	FOXP3		P	FOXP3 immunohistochemistry intensity score				P
		Positive	Negative		0	1	2	3
Gender
Male	119	28 (24)	91 (76)	0.61932	91 (76)	20 (17)	7 (6)	1 (1)	0.48951
Female	21	6 (28)	15 (72)		15 (72)	3 (14)	3 (14)	0 (0)
Age (yr)
> 60	30	9 (30)	21 (70)	0.41032	21 (70)	4 (13)	5 (17)	0 (0)	0.15421
≤ 60	110	25 (23)	85 (77)		85 (77)	19 (17)	5 (5)	1 (1)
Differentiation grade
Well	32	11 (34)	21 (66)	0.24102	21 (66)	8 (25)	2 (6)	1 (3)	0.28871
Moderate	73	14 (19)	59 (81)		59 (81)	8 (11)	6 (8)	0 (0)
Poor	35	9 (26)	26 (74)		26 (74)	7 (20)	2 (6)	0 (0)
Tumor	140	34 (24)	106 (76)	0.04051a	106 (76)	23 (16)	10 (7)	1 (1)
Normal	14	0 (0)	14 (100)		14 (100)	0 (0)	0 (0)	0 (0)

¹Fisher's exact test;

²Pearson χ².

^aP < 0.05. FOXP3: Forkhead box protein 3.

Table 3 Relationship between hepatitis B virus infection (or cirrhosis) distribution and forkhead box protein 3 expression in 21 hepatocellular carcinoma samples

		FOXP3 expression		P
		-	+
HBV infection	-	2	1	0.021a
	+	9	9
Cirrhosis	-	1	3	0.092
	+	10	7

FOXP3: Forkhead box protein 3; HBV: Hepatitis B virus.

^aP < 0.05.