Brief Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Jul 21, 2010; 16(27): 3432-3436
Published online Jul 21, 2010. doi: 10.3748/wjg.v16.i27.3432
Table 1 Demographic data, Helicobacter status, and smoking in gastric cancer patients and control subjects
VariableGC patientsControl
No. of subjects192170
Age (yr), mean ± SD32.8 ± 6.655.1 ± 12.5
Male, %58.3056.50
H. pylori status, n1161901
Positive, n (%)67 (58)54 (60)
Table 2 Clinicopathological features of 192 gastric cancer patients
Variablen (%)
Lauren’s classification
Intestinal93 (48.5)
Mixed and diffuse99 (51.5)
Histological grade
G111 (5.8)
G280 (41.6)
G3101 (52.6)
T stage
T1 + T232 (16.7)
T3 + T4160 (83.3)
Lymph node involvement
Negative26 (13.5)
Positive166 (86.5)
TNM stage
I + II33 (17.2)
III + IV159 (82.8)
Table 3 CDH1 genotype frequencies and their associated risk of gastric cancer predisposition
CDH1 genotypePatients n (%)1Control n (%)1OR2 (95% CI)P value
+ 54 T>Cn = 174n = 157
TT25 (14.4)22 (14.0)1
TC70 (40.2)75 (47.8)0.9 (0.4-2.2)0.9
CC79 (45.4)60 (38.2)0.9 (0.4-2.4)0.8
CC + TC149 (85.6)135 (86.0)0.9 (0.4-2.1)0.8
TT + TC95 (54.6)97 (61.8)1.0 (0.5-2.0)1.0
C allele66.062.0
-160 C>An = 174n = 166
CC93 (53.6)93 (56.0)1
CA60 (34.5)65 (39.2)0.6 (0.3-1.1)0.1
AA21 (12.0)8 (4.8)3.6 (1.1-11.8)0.03
AA + CA81 (46.5)73 (44.0)0.8 (0.4-1.5)0.8
CC + CA153 (88.1)158 (95.2)3.4 (1.4-13.9)0.01
A allele29.024.0
-616 G>Cn = 172n = 159
GG84 (48.8)71 (44.7)1
GC65 (37.8)69 (43.4)0.9 (0.6-1.8)0.7
CC23 (13.4)19 (12.0)1.8 (0.6-5.1)0.3
GC + CC88 (51.2)88 (55.4)1.0 (0.6-1.9)0.9
GG + GC149 (86.6)140 (88.1)1.8 (0.7-5.2)0.3
C allele32.034.0
-3159 T>Cn = 177n = 166
TT52 (29.7)47 (28.3)1
TC72 (41.1)78 (47.0)0.9 (0.4-1.7)0.7
CC53 (30.3)41 (24.7)1.0 (0.5-2.0)0.9
CC + TC125 (71.4)119 (71.7)0.9 (0.5-1.7)0.8
TT + TC124 (70.8)125 (75.3)1.1 (0.54-2.2)0.8
C allele50.048.0
Table 4 Frequencies of CDH1 haplotypes and associated risk of gastric cancer predisposition
HaplotypeFrequency (%)
OR1 (95% CI)P value
PatientControl
TCGT20.122.11
TACG10.411.00.99 (0.5-1.9)1.0
CCGT16.517.71.0 (0.5-1.8)1.0
CCGC7.05.01.5 (0.7-3.5)0.3
CCCT11.19.91.1 (0.5-2.3)0.8
CCCC15.116.60.9 (0.6-1.6)0.8
CAGC10.77.11.5 (0.8-3.0)0.2
CACC5.85.71.1 (0.5-2.4)0.8