Correlation between expression and differentiation of endocan in colorectal cancer

Table 1 Differential expression of endocan mRNA and protein in normal and colon cancer tissues

Type	n	Expression of endocan mRNA		Positive (%)	P
		+	-
Normal mucous membrane	27	25	2	92.6	0.001
Colon carcinoma tissue	72	24	48	33.3	(χ2 = 25.266)

Table 2 Differential expression of endocan protein in normal and colorectal cancer tissues

Type	n	Expression of endocan protein		Positive (%)	P
		+	-
Normal mucous membrane	27	19	8	70.4	0.005
Colon carcinoma tissue	72	26	46	36.1	(χ2 = 7.965)

Table 3 Correlation of endocan mRNA and protein expression with clinical pathological parameters

Group		n	Endocan mRNA				Endocan protein
			+	-	Positive (%)	P	+	-	Positive (%)	P
Age	≤ 54	34	10	24	29.4	0.676 (χ2 = 0.174)	11	23	32.4	0.702 (χ2 = 0.146)
	> 54	38	14	24	36.8		15	23	39.5
Sex	Male	23	9	14	39.1	0.919 (χ2 = 0.01)	10	13	43.5	0.530 (χ2 = 0.395)
	Female	49	17	32	34.7		16	33	32.7
Size	≤ 3	11	3	8	27.3	0.643a	5	6	45.5	0.483a
	> 3	61	21	40	34.4		21	40	34.4
Infiltration	Full-thickness	64	21	43	32.8	0.791a	21	43	32.8	0.099a
	Non-full-thickness	8	3	5	37.5		5	3	62.5
Metastasis	Nonmetastatic tumor	27	8	19	29.6	0.796 (χ2 = 0.067)	9	18	33.3	0.899a
	Metastatic tumor	45	16	29	35.6		17	28	37.8
Grade	Differentiated (well + moderately)	57	23	34	40.4	0.031 (χ2 = 4.642)	26	31	45.6	0.003 (χ2 = 8.824)
	Poorly differentiated	15	1	14	6.7		1	14	6.7
TNM stage	I and II	43	18	25	41.9	0.324 (χ2 = 0.973)	18	25	41.9	0.324 (χ2 = 0.973)
	III and IV	29	8	21	27.6		8	21	27.6

^aP < 0.05 vs controls.