Basic Research
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 21, 2008; 14(23): 3710-3718
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3710
Table 1 Characteristics of chronic HBV-infected individuals with normal liver function tests
CharacteristicsAll individualsMaternal HBV-infection status (MH)
(n = 216)Individuals with MH (n = 129)Individuals without MH (n = 87)P
Sex (male/female)125/9175/5450/370.9221
Mean age (yr)31.53 ± 11.2329.11 ± 11.4435.13 ± 9.94< 0.0012
Age of HBV-infection (yr) (%)< 0.0011
< 880 (37.0)62 (48.1)18 (20.7)
8-2056 (25.9)36 (27.9)20 (23.0)
> 2058 (26.9)21 (16.3)37 (42.5)
Unknown22 (10.2)10 (7.8)12 (13.8)
HBV DNA positive (%)136 (63.0)106 (82.2)30 (34.5)< 0.0011
Serum HBV DNA (copies/mL) (%)< 0.0011
≤ 1.0 × 10380 (37.0)23 (17.8)57 (65.5)
1.0 × 103-1.0 × 10514 (6.5)5 (3.9)9 (10.3)
1.0 × 105-1.0 × 10729 (13.4)17 (13.2)12 (13.8)
> 1.0 × 10793 (43.1)84 (65.1)9 (10.3)
HBV DNA load (log, copies/mL)5.90 ± 2.617.13 ± 2.364.07 ± 1.74< 0.0012
HBeAg positive (%)122 (56.5)97 (75.2)25 (28.7)< 0.0011
Table 2 Peripheral T-cell subsets in normal control and CHI individuals broken down by various factors (mean ± SD)
GroupsnCD3+ (%)CD4+ (%)CD8+ (%)CD4+/CD8+ ratio
HBV status1
Negative10071.07 ± 4.7638.94 ± 3.3924.02 ± 4.351.67 ± 0.33
Positive21657.35 ± 13.8132.97 ± 7.0033.08 ± 7.991.07 ± 0.41
Maternal HBV-infection status1
Negative8764.67 ± 10.7435.75 ± 6.0828.71 ± 5.561.29 ± 0.35
Positive12952.42 ± 13.4931.10 ± 6.9836.03 ± 8.040.93 ± 0.38
Age at HBV-infection (yr)
< 88066.35 ± 8.1930.78 ± 7.0335.36 ± 7.120.91 ± 0.30
8-205666.46 ± 9.3331.65 ± 5.0635.80 ± 7.790.93 ± 0.28
> 205869.35 ± 9.8536.37 ± 7.31df28.22 ± 7.11dh1.37 ± 0.46dh
Unknown2269.35 ± 9.8535.35 ± 6.62a30.69 ± 7.48bf1.24 ± 0.46af
HBV DNA load (copies/mL)2
≤ 1.0 × 1038065.84 ± 9.3937.11 ± 6.2928.12 ± 5.651.38 ± 0.40
1.0 × 103-1.0 × 1051465.36 ± 5.1534.70 ± 2.7928.66 ± 6.211.28 ± 0.38
1.0 × 105-1.0 × 1072966.20 ± 9.9933.66 ± 6.3932.40 ± 6.541.06 ± 0.24
> 1.0 × 1079346.09 ± 10.5228.94 ± 5.9538.23 ± 7.210.79 ± 0.22
HBeAg status1
Negative9464.45 ± 10.4435.81 ± 6.6929.05 ± 6.431.30 ± 0.42
Positive12251.89 ± 13.6330.78 ± 6.4636.19 ± 7.690.89 ± 0.31
Table 3 Multiple linear regression predicting peripheral blood T lymphocyte subpopulation (n = 216)
CD3+ T lymphocyte
CD4+ T lymphocyte
CD8+ T lymphocyte
CD4+/CD8+ ratio
βSEPβSEPβSEPβSEP
Intercept79.543.03-40.091.78-25.781.88-1.50.09-
Serum HBV load (log, copies/mL)1-3.650.43< 0.0001-1.380.25< 0.00011.360.26< 0.0001-0.080.01< 0.0001
HBeAg negative0.051.980.980.611.160.60.51.220.69-0.020.060.74
Age at HBV-infection(yr)20.060.630.190.02
8-20-1.531.80.271.051.521.11-0.030.05
> 20-4.772.081.21.22-1.281.280.150.06
Unknown1.282.551.641.49-0.771.580.130.08
Maternal HBV-infection status2.171.740.210.311.020.77-2.451.080.020.060.050.27