Association between the presence of H pylori in the liver and hepatocellular carcinoma: A meta-analysis

Table 1 Characteristics of 10 studies investigating the association between the presence of H pylori infection in liver and hepatocellular carcinoma

Reference	Country, year of publication	H pyloripositivity/total subjects		Type of controls (n)	Age range (mean), yr
		Cases	Controls		Cases	Controls
Pellicano et al[6]	Italy, 2004	17/20	2/6	Metastatic cancer (n = 6)	NA	NA
Ito et al[7]	Japan, 2004	13/15	0/17	Cirrhotic liver tissue specimens (n = 10), normal liver tissue specimens (n = 7)	36-73 (59.2)	NA
Coppola et al[8]	Italy, 2003	0/21	0/34	Metastatic liver carcinoma (n = 7), chronic hepatitis (n = 27)	NA	NA
Dore et al[9]	Italy, 2002	6/11	5/30	Chronic viral hepatitis without (n = 18) or with (n = 12) cirrhosis	19-78 (54.9)	49-78 (65.2)
Avenaud et al[10]	France, 2000	8/8	1/8	Patients without primary liver carcinoma (n = 8)	NA	NA
Nilsson et al[11]	Sweden, 2001	12/16	0/20	Metastatic liver carcinoma (n = 20)	NA	NA
Zhang et al[12]	China, 2004	16/48	2/37	Liver cirrhosis (n = 12), pericacinomatous tissues (n = 10), benign tumor of liver (n = 9), chronic hepatitis (n = 6)	25-67 (46.5)	35-65 (42.5)
Huang et al[13]	China, 2004	16/38	0/30	Liver cirrhosis (n = 15), benign tumor of liver (n = 15)	NA	NA
Li N et al[14]	China, 2006	22/34	0/20	Liver external injury (n = 5) giant hemangioma (n = 5), macrosis hepatic cyst (n = 3), ntrahepatic bile duct stone (n = 7)	28-71 (52)	30-68 (48)
Rocha et al[15]	France, 2005	19/31	19/78	Non-cirrhotic chronic hepatitis C (n = 24), HCV Positive cirrhosis without HCC (n = 29), HCV Positive cirrhosis and HCC (n = 25)	NA	NA