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Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jan 14, 2008; 14(2): 307-312
Published online Jan 14, 2008. doi: 10.3748/wjg.14.307
Association between the presence of H pylori in the liver and hepatocellular carcinoma: A meta-analysis
Shi-Ying Xuan, Yong-Ning Xin, An-Jin Chen, Quan-Jiang Dong, Xin Qiang, Ning Li, Ming-Hua Zheng, Hua-Shi Guan
Shi-Ying Xuan, Hua-Shi Guan, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, Shandong Province, China
Shi-Ying Xuan, Yong-Ning Xin, An-Jin Chen, Quan-Jiang Dong, Ning Li, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao 266021, Shandong Province, China
Xin Qiang, Department of Microbiology, School of Medicine, Qingdao University, Qingdao 266021, Shandong Province, China
Ming-Hua Zheng, Department of Infection and Liver Disease, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, Zhejiang Province, China
Correspondence to: Hua-Shi Guan, College of Medicine and Pharmaceutics, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong Province, China. dxyxyn@gmail.com
Telephone: +86-532-88905508
Fax: +86-532-82031522
Received: June 28, 2007
Revised: October 13, 2007
Published online: January 14, 2008

AIM: To evaluate the arguments for and against the possible roles of H pylori in hepatocellular carcinoma (HCC).

METHODS: We performed a systematic review of all relevant studies published in the literature. A total of 103 clinical trials and reports were identified, but only 10 trials qualified under our selection criteria. A meta-analysis was carried out by a biostatistician according to the Cochrane Reviewers’ Handbook recommended by The Cochrane Collaboration.

RESULTS: Nine case-control studies and one retrospective cross sectional study were included in the final analysis. Overall the prevalence of H pylori infection was 53.3% (129 of 242) in cases and 10.4% (29 of 280) in controls, and the summary odds ratio for the association of H pylori infection with the risk for HCC (using the fixed-effects model, which accounted for the homogeneity across the 10 studies) was determined to be 13.63 (95% CI, 7.90-23.49).

CONCLUSION: Our analysis showed a positive association between H pylori infection and the risk of HCC, with an indication of possible publication bias and possible confounders due to study designs that showed results of less pronounced associations.

Keywords: H pylori, Hepatocellular carcinoma, Meta-analysis, Publication bias