A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity

doi:10.3748/wjg.v13.i39.5196

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Oct 21, 2007 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2007; 13(39): 5196-5207
Published online Oct 21, 2007. doi: 10.3748/wjg.v13.i39.5196

Table 1 Toxicity studies with Swallow root pectic polysac-charide (n = 6) mean ± SD

Parameters	Control	SRPP treated
Total protein	348^a± 32.21	361.81^a± 28.10
SGOT (U/mg protein)	18.34^a± 1.55	16.22^a± 1.34
SGPT (U/mg protein)	21.31^a± 2.70	23.21^a± 2.29
ALP (U/mg protein)	35.52^a± 3.879	33.62^a± 2.95
TBARS (n moles/mg protein)	0.166^a± 0.08	0.186^a± 0.11

SGPT: Serum glutamate pyruvate transaminase; SGOT: Serum glutamate oxaloacetate transaminase; ALP: Alkaline phosphatase; TBARS: Thiobarbituric acid reactive substances.

^aP < 0.05 between control and SRPP treated groups.

Table 2 Gastric mucin and H⁺, K⁺-ATPase levels in healthy, ulcerated and protected rats (n = 6) mean ± SD

Group, n = 6	Mucin content (mg/g)	H⁺, K⁺-ATPase (μmoles Pi released/mg/h)
Healthy	45.04^d± 4.128	0.807^d± 0.072
Swim stress induced ulcer model
Swim stress induced	17.78^a± 2.557	2.209^a± 0.152
SRPP 100 mg/kg b.w.	27.13^b± 4.082	1.771^b± 0.081
SRPP 200 mg/kg b.w.	35.35^c± 3.221	1.601^b± 0.091
Ranitidine 50 mg/kg b.w.	31.42^b,c± 2.327	1.621^b± 0.092
Ethanol stress induced ulcer model
Ethanol stress induced	16.32^a± 3.821	2.621^a± 0.211
SRPP 100 mg/kg b.w.	32.13^b± 3.457	2.123^b± 0.241
SRPP 200 mg/kg b.w.	39.53^b,c± 3.082	1.512^c± 0.121
Ranitidine 50 mg/kg b.w.	37.13^b± 1.507	1.485^c± 0.124

Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups. Range was provided by Duncan multiple test at P < 0.05. a: Less significant; b: Moderately significant; c: Very significant and d: Most significant.

Table 3 Antioxidant/antioxidant enzymes and TBARS levels in swim stress induced ulcer model (n = 6) mean ± SD

Parameters	Protein (mg/g)	SOD (U/mg)	Catalase (U/mg)	Glutathione Peroxidase (ηmoles/g)	GSH (nmoles/mg)	TBARS ηmoles
Stomach
Healthy	2.23^c± 0.21	9.86^a± 1.1	829.2^c± 41.6	0.21^a± 0.009	224^c± 10.0	0.31^a± 0.01
Ulcerated	1.95^a± 0.13	19.10^c± 1.8	462.4^a± 30.2	0.49^d± 0.01	121^a± 18.9	1.12^c± 0.20
SRPP 100 mg/kg	1.90^a± 0.09	16.32^b,c± 2.1	488.1^a,b± 32.8	0.34^b± 0.02	174^b± 22.1	0.94^c± 0.10
SRPP 200 mg/kg	2.10^b± 0.19	13.06^b± 2.6	679.6^b± 9.9	0.22^a± 0.01	208^c± 16.5	0.55^a,b± 0.00
Ranitidine	2.16^b± 0.22	15.22^b± 1.2	505.5^a,b± 35.5	0.39^c± 0.01	136^a± 12.1	0.92^b± 0.10
Serum
Healthy	6.62^a± 0.51	112.3^a± 28	44.20^c± 4.9	0.221^a± 0.004	23.6^c± 3.0	0.165^a± 0.01
Ulcerated	6.84^a± 0.53	264.6^d± 32	22.90^a± 3.1	0.286^c± 0.02	11.1^a± 1.8	0.326^d± 0.02
SRPP 100 mg/kg	6.35^a± 0.59	201.1^c± 36	28.63^b± 2.3	0.298^d± 0.03	16.5^b± 2.1	0.261^c± 0.03
SRPP 200 mg/kg	6.95^a± 0.48	168.2^b± 21	40.12^c± 3.8	0.268^b± 0.03	19.8^b,c±12.9	0.162^a± 0.01
Ranitidine	6.35^a± 0.63	196.3^b,c±23	30.82^b± 2.9	0.226^a± 0.02	12.8^a± 2.6	0.186^b± 0.01
Liver
Healthy	24.2^c± 0.31	261.5^b± 41	28.42^d± 3.1	0.32^a± 0.02	414^c± 51	0.98^a± 0.13
Ulcerated	21.9^a± 0.23	142.4^a± 18	22.18^b,c± 2.6	0.58^c± 0.05	221^a± 26	2.41^d± 0.23
SRPP 100 mg/kg	23.1^b± 0.28	164.2^a± 13	19.63^b,c± 2.4	0.36^a,b± 0.03	315^b± 36	1.84^c± 0.16
SRPP 200 mg/kg	23.9^b± 0.28	361.5^d± 39	15.54^a± 2.1	0.28^a± 0.02	214^a± 24	1.26^b± 0.11
Ranitidine	23.6^b± 0.26	314.4^c,d± 36	17.34^a± 1.9	0.32^a± 0.02	254^a± 28	1.41^b± 0.12

SOD: Superoxide dismutase; GSH: Glutathione; TBARS: Thiobarbituric acid reactive substances. Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups.

Table 4 Antioxidant/antioxidant enzymes and TBARS levels in ethanol induced ulcer model (n = 6) mean ± SD

Parameters	Protein (mg/g)	SOD (U/mg)	Catalase (U/mg)	Glutathione Peroxidase (ηmoles/g)	GSH (U/mg)	TBARS ηmoles
Stomach
Healthy	2.23^a± 0.21	09.86^a± 1.1	829.2^c± 41.6	0.21^a± 0.009	224^d± 23.2	0.31^a± 0.1
Ulcerated	2.32^a± 0.09	17.86^c± 2.4	201.5^a± 18.9	0.30^c± 0.01	102^a± 12.6	1.26^d± 0.3
SRPP 100 mg/kg	2.16^a± 0.16	16.21^c± 1.0	193.3^a± 62.5	0.26^b± 0.01	162^b± 15.5	0.92^c± 0.1
SRPP 200 mg/kg	2.41^a± 0.20	11.09^b± 1.0	540.5^b± 40.2	0.33^c± 0.02	196^c± 16.4	0.54^b± 0.1
Ranitidine	2.42^a± 0.19	12.42^b±1.4	468.6^c± 31.6	0.22^a± 0.03	152^b± 16.3	0.96^c± 0.2
Serum
Healthy	6.62^a± 0.51	112.3^a± 28	44.20^c± 4.9	0.221^a± 0.04	23.6^d± 3.0	0.165^a± 0.01
Ulcerated	6.52^a± 0.69	282.3^d± 26	28.36^a± 3.2	0.315^c± 0.03	9.6^a± 1.2	0.465^d± 0.03
SRPP 100 mg/kg	6.35^a± 0.70	228.4^c± 32	34.25^a,b± 3.3	0.286^b± 0.03	18.6^c± 2.2	0.321^c± 0.04
SRPP 200 mg/kg	6.24^a± 0.56	172.3^b± 2	39.60^b± 4.51	0.243^b± 0.02	18.2^c± 1.9	0.181^a± 0.02
Ranitidine	6.32^a± 0.69	210.7^c±28	34.12^ab± 4.6	0.252^b± 0.03	14.6^b± 1.6	0.214^a,b± 0.02
Liver
Healthy	24.2^a± 0.31	261.5^b± 1.1	28.42^c± 3.1	0.32^b± 0.02	414^c± 51	0.98^a± 0.13
Ulcerated	24.3^a± 0.31	118.1^a± 16	19.64^b± 2.2	0.48^b,c± 0.03	392^b,c± 41	2.98^d± 0.31
SRPP 100 mg/kg	23.5^a± 0.21	121.8^a± 15	18.32^b± 1.6	0.39^b± 0.03	268^b± 25	2.15^c± 0.22
SRPP 200 mg/kg	26.4^a± 0.41	325.4^c± 34	13.17^a± 1.6	0.29^a± 0.02	241^a,b± 28	1.65^b± 0.14
Ranitidine	26.8^a± 0.29	254.5^b± 26	14.24^a± 1.8	0.31^a± 0.03	211^a± 28	1.61^b± 0.16

Range was provided by Duncan multiple test at P < 0.05. a: Less significant; b: Moderately significant; c: Very significant and d: most significant. Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups.

Citation: Srikanta B, Siddaraju M, Dharmesh S. A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity. World J Gastroenterol 2007; 13(39): 5196-5207
URL: https://www.wjgnet.com/1007-9327/full/v13/i39/5196.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i39.5196