Preparation method of an ideal model of multiple organ injury of rat with severe acute pancreatitis

Table 1 Comparison of ascites volume in all groups [M(Q_R)]

Groups	3 h	6 h	12 h
Sham operation group	0.50 (0.00)	0.70 (0.50)	0.60 (0.30)
Model group	7.20 (2.00)	6.40 (2.30)	7.90 (1.70)

P < 0.001 at all time points between model group and sham operation group.

Table 2 Comparison of ascites/body weight ratio [M(Q_R)]

Groups	3 h	6 h	12 h
Sham operation group	0.20 (0.04)	0.30 (0.30)	0.22 (0.10)
Model group	2.38 (1.10)	2.58 (0.70)	2.54 (0.71)

P < 0.001 at all time points between model group and sham operation group.

Table 3 Comparison of different indexes level in blood [M (Q_R) or (mean ± SD)]

Index	Sham operation group			Model group
	3 h	6 h	12 h	3 h	6 h	12 h
Amylase (U/L)	1582 (284)	1769 (362)	1618 (302)	5303 (1373)	6276 (1029)	7538 (2934)
Endotoxin (EU/mL)	0.016 (0.005)	0.016 (0.01)	0.014 (0.015)	0.053 (0.029)	0.059 (0.037)	0.060 (0.022)
ET-1 (ng/L)	15.293 (4.231)	16.275 (3.180)	14.173 (2.556)	24.745 (1.011)	25.625 (7.973)	24.725 (3.759)
NO (μmol/L)	7.500 (5)	7.500 (5)	10.000 (5)	65.000 (7.5)	62.500 (38.8)	74.100 (26.2)
TNF-α (ng/L)	3.900 (3.200)	4.000 (1.7)	5.300 (3.000)	41.438 (37.721)	92.151 (23.119)	65.016 (26.806)
IL-6 (ng/L)	1.846 (0.346)	1.743 (0.838)	2.036 (0.818)	5.437 (1.025)	6.817 (0.81)	5.356 (0.747)
PLA2 (U/mL)	18.70 ± 4.40	16.70 ± 3.83	18.52 ± 11.32	103.69 ± 20.82	119.85 ± 17.74	121.29 ± 17.00

P < 0.01 at all time points between model group and sham operation group.