Effects of hypobaric hypoxia on adenine nucleotide pools, adenine nucleotide transporter activity and protein expression in rat liver

Table 1 Changes of total adenine nucleotide pool in liver tissue during hypoxia exposure (nmol/mg tissue, mean±SD)

Group	n	AMP	ADP	ATP
H0	6	9.32 ± 1.63	9.02 ± 0.87	4.00 ± 0.26
H1	6	7.14 ± 1.41	5.53 ± 0.71b	2.40 ± 0.29b
H5	6	4.90 ± 0.74b	4.57 ± 0.48b	2.41 ± 0.17b
H15	6	6.08 ± 1.57a	5.40 ± 1.31b	3.11 ± 0.25b
H30	6	6.58 ± 1.19a	6.21 ± 1.36b	3.27 ± 0.30b

^aP < 0.05, ^bP < 0.01 vs H0 group.

Table 2 Changes of intra-mitochondrial adenine nucleotide pool of rat liver during hypoxia exposure (nmol/mg protein, mean±SD

Group	n	AMP	ADP	ATP
H0	6	6.84 ± 1.57	11.34 ± 1.97	5.47 ± 0.54
H1	6	3.68 ± 0.42b	4.52 ± 1.07b	3.86 ± 0.20b
H5	6	2.72 ± 1.09b	4.76 ± 1.56b	4.03 ± 0.25b
H15	6	3.94 ± 0.68b	5.07 ± 0.10b	4.50 ± 0.35b
H30	6	3.77 ± 0.67b	8.70 ± 2.11b	4.72 ± 0.60a

^aP < 0.05, ^bP < 0.01 vs H0 group.

Table 3 Changes of adenine nucleotide pool in extra-mitochondria of rat liver during hypoxia exposure (nmol/mg tissue, mean±SD)

Group	n	AMP	ADP	ATP
H0	6	8.64 ± 1.58	8.08 ± 0.93	3.45 ± 0.22
H1	6	6.77 ± 1.40	5.07 ± 0.74b	2.01 ± 0.27b
H5	6	4.63 ± 0.82b	4.09 ± 0.60b	2.01 ± 0.15b
H15	6	5.68 ± 1.60a	4.90 ± 1.34b	2.67 ± 0.27b
H30	6	6.21 ± 2.01a	5.37 ± 1.53b	2.80 ± 0.33a

^aP < 0.05, ^bP < 0.01 vs H0 group.