Cerebral processing of auditory stimuli in patients with irritable bowel syndrome

doi:10.3748/wjg.v12.i11.1723

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Mar 21, 2006; 12(11): 1723-1729
Published online Mar 21, 2006. doi: 10.3748/wjg.v12.i11.1723

Table 2 Significant activations (signal increase) and deactivations (signal decrease) induced by different acoustic stimuli

I) PEEP			¹Largest cluster
A: Control deactivation
RoI	Side	No. of	No. of	x¹	y¹	z¹	% signal
RoI	Side	Clusters	Voxels1	x¹	y¹	z¹	change*
ACC	L	1	-793	-8	37	-10	-0.53
PFC	B	7	-1506	37	35	-7	-0.52
B: IBS deactivation
ACC	L	1	-271	-6	31	7	-0.28
PFC	B	7	-1724	23	57	8	-0.52
Amyg - dala	R	1	-452	25	1	-20	-0.33
HC	B	2	-436	33	-22	-24	-0.38
II) CHIMES
A: Control activation
ACC	B	1	699	-1	29	2	0.40
PFC	B	7	1957	-4	37	-6	0.39
Deactivation
PFC	B	4	-1781	31	47	23	-0.48
PCC	L	1	-707	-5	-4	51	-0.24
Insula	R	1	-850	32	1	7	-0.25
HC	R	1	-113	26	-14	-15	-0.14
B: IBS deactivation
ACC	B	2	-1212	2	18	44	-0.38
PCC	B	1	-159	0	-17	32	-0.36
PFC	R	3	-2095	54	13	13	-0.42
III) EMOTIONAL WORDS			¹Largest cluster
A: Control deactivation
ACC	L	1	-724	-5	36	13	-0.33
PFC	B	4	-275	-4	47	-2	-0.36
PCC	L	1	-134	-1	-33	44	-0.35
PSAC	B	1	-2048	0	-62	33	-0.36
HC	R	1	-31	25	-24	-15	-0.21
B: IBS activation
PFC	L	1	609	-46	29	-1	0.25
Deactivation
ACC	R	1	-1207	2	40	5	-0.41
PFC	B	4	-2076	9	43	26	-0.32
PSAC	B	1	-2048	0	-46	42	-0.35
HC	B	2	-1010	24	-35	-12	-0.29
Insula	R	1	-331	34	-10	1	-0.19
IV) NEUTRAL WORDS
A : Controls activation
PFC	R	1	45	26	55	6	0.40
PSAC	R	1	45	26	-42	53	0.05
Deactivation
ACC	L	1	-118	-3	31	-6	-0.44
B : IBS activation
ACC	R	2	223	1	6	46	0.19
PFC	B	8	1408	0	46	-11	0.18
PSAC	B	4	257	26	-65	41	0.08
HC	B	2	652	27	-27	19	0.14
PCC	L	2	102	-2	-39	37	0.12

RoI= region of interest, R=right, L=left, B= bilateral, ACC= anterior cingulate cortex, PCC= Posterior Cingulate Cortex, PFC=prefrontal cortex, PSAC=parietal sensory association cortex, HC=hippocampus, x+y+z=coordi- nates of the Talairach space.

Table 1 Personality characteristics (mean ± SD)

Personality test	Control	IBS	IBS vs control	Reference- population [18-20]
STAI X2	34.8 ± 6.1	41.3 ± 11.0	P = 0.17	35.7 ± 9.4
BDI	5.4 ± 5.3	8.7 ± 4.4	P = 0.19	6.5 ± 5.2
NEO: Neuroticism	1.7 ± 0.5	2.2 ± 0.6	P = 0.11	1.8 ± 0.7
NEO: Extroversion	2.8 ± 0.4	2.6 ± 0.3	P = 0.24	2.4 ± 0.6
NEO: Openness to experience	2.5 ± 0.5	2.4 ± 0.3	P = 0.73	2.7 ± 0.5
NEO: Agreeableness	2.4 ± 0.6	2.4 ± 0.3	P = 0.81	2.4 ± 0.5
NEO: Consciousness	3.0 ± 0.6	3.2 ± 0.5	P = 0.46	2.6 ± 0.6

STAI=State-Trait-Anxiety-Inventory, with X2=Trait-Anxiety Subtest, BDI= Beck’s Depression Index, NEO= NEO-Five-Factor-Inventory

Citation: Andresen V, Poellinger A, Tsrouya C, Bach D, Stroh A, Foerschler A, Georgiewa P, Schmidtmann M, Voort IRVD, Kobelt P, Zimmer C, Wiedenmann B, Klapp BF, Monnikes H. Cerebral processing of auditory stimuli in patients with irritable bowel syndrome. World J Gastroenterol 2006; 12(11): 1723-1729
URL: https://www.wjgnet.com/1007-9327/full/v12/i11/1723.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i11.1723