Role of adhesion molecules and dendritic cells in rat hepatic/renal ischemia-reperfusion injury and anti-adhesive intervention with anti-P-selectin lectin-EGF domain monoclonal antibody

doi:10.3748/wjg.v11.i7.1005

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Feb 21, 2005 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2005; 11(7): 1005-1010
Published online Feb 21, 2005. doi: 10.3748/wjg.v11.i7.1005

Table 1 Dendritic cell distribution in rat hepatic tissue among the three groups.

Group	n	Area (mm²) of CD1a⁺CD80⁺DCs	Number of CD1a⁺CD80⁺ DCs	Density (n/mm²) of CD1a⁺CD80⁺ DCs
Sham-operated	5	415.8±259.4	98.5±56.8	626.4±291.5
Saline-treated	20	3 542.6±2 435.8^d	1 035.6±984.2^d	2 654.3±1 025.4^d
Anti-PsL-EGFmAb-treated	20	1 982.7±1 456.4^b^f	625.4±341.3^b^f	962.8±659.1^b^f

^bP<0.01,

^dP<0.001 vs sham-operated group;

^fP<0.01 vs saline-treated group.

Table 2 Dendritic cell distribution in rat renal tissue among the three groups.

Group	n	Area (mm²) of CD1a⁺CD80⁺DC	Number of CD1a⁺CD80⁺DC	Density (n/mm²) of CD1a⁺CD80⁺DC
Sham-operated	5	356.3±232.0	84.5±63.7	575.3±280.1
Saline-treated	20	2 726.9±1 678.4^d	866.9±685.4^d	1647.5±1 376.8^d
Anti-PsL-EGFmAb-treated	20	1 610.7±1 025.3^b^f	383.4±257.6^b^f	932.6±754.1^b^f

^bP<0.01,

^dP<0.001 vs sham-operated group;

^fP<0.01 vs saline-treated group.

Table 3 Dendritic cell distribution at different time points after reperfusion between saline-treated and anti-PsL-EGFmAb-treated groups.

	n	CD1a⁺CD80⁺ DCs (n/mm²) in rat hepatic tissue		CD1a⁺CD80⁺ DCs (n/mm²) in rat renal tissue
	n	Saline-treated	Anti-PsL-EGFmAb-treated	Saline-treated	Anti-PsL-EGFmAb-treated
1 h	5	1239.7±965.2	632.7±425.3^a	1076.4±563.9	573.5±376.8^a
3 h	5	1364.5±1025.4	671.9±654.1^a	1132.5±925.7	659.8±475.2^a
6 h	5	1748.9±1085.1	967.2±977.5^a	1435.6±952.8	975.3±612.8^a
24 h	5	3428.6±1594.5	1249.4±872.9^b	2864.3±2041.5^d	1256.2±956.4^b

^aP<0.05,

^bP<0.01 vs saline-treated group,

^dP<0.01 vs 1 h, 3 h or 6 h group.

Citation: Zhou T, Sun GZ, Zhang MJ, Chen JL, Zhang DQ, Hu QS, Chen YY, Chen N. Role of adhesion molecules and dendritic cells in rat hepatic/renal ischemia-reperfusion injury and anti-adhesive intervention with anti-P-selectin lectin-EGF domain monoclonal antibody. World J Gastroenterol 2005; 11(7): 1005-1010
URL: https://www.wjgnet.com/1007-9327/full/v11/i7/1005.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i7.1005