Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma

Table 1 Clinical features of the studied subjects with operable HCC

Case	Sex	Age	HBs Ag positivity	Cirrhosis	Tumor stage		Tumor size	Tumor	Encapsulation	Capsule invasion	Vascular invasion	Preoperative serum
					ALTSG AJCC		(cm)	differentiation				AFP (ng/mL)
1	F	51	Yes	Yes	T2	T2	2.4	Moderate	Yes	Yes	No	20
2	M	75	Yes	Yes	T2	T2	3.4	Moderate	Yes	Yes	No	25
3	M	52	Yes	No	T3	T2	10	Moderate	Yes	No	No	64
4	M	44	Yes	Yes	T3	T3	4	Well	Yes	Yes	Yes	69
5	M	44	No	Yes	T2	T2	2.6	Poor	Yes	Yes	No	73
6	M	53	Yes	Yes	T3	T2	8.3	Poor	Uncertain	Uncertain	No	100
7	M	65	No	Yes	T2	T2	4.4	Moderate	Yes	No	No	150
8	F	41	Yes	Yes	T3	T2	7	Well	Yes	Yes	No	151
9	M	57	No	Yes	T3	T2	6	Poor	Yes	Yes	Yes	152
10	M	46	Yes	Yes	T1	T1	1.2	Moderate	Yes	Yes	No	365
11	M	60	Yes	Yes	T2	T2	2.2	Poor	Yes	Yes	No	618
12	M	67	Yes	Yes	T2	T2	2.5	Moderate	Yes	Yes	No	1 057
13	M	48	Yes	No	T2	T2	4	Moderate	Yes	No	No	1 427
14	M	43	Yes	No	T2	T2	2.5	Moderate	Yes	Yes	No	1 500
15	F	31	Yes	Yes	T2	T2	2	Moderate	Yes	No	No	2 726
16	M	40	Yes	No	T2	T2	1.6	Moderate	No	No	No	3 338
17	M	35	Yes	No	T3	T2	8	Poor	Yes	No	No	5 505
18	M	42	Yes	Yes	T2	T2	3.4	Poor	Yes	Yes	No	12 185
19	M	72	Yes	No	T3	T3	6.5	Poor	Yes	Yes	No	42 837

Table 2 The average values of relative ST6Gal I activity, the relative ST6Gal I mRNA level, serum msAFP percentage in the patients with decreased (group 1) and increased (group 2) tumor ST6Gal I activity compared to that of non-tumorous tissue

	Group 1: decreased ST6Gal	Group 2: increased ST6Gal	P1
	(n = 7)	(n = 12)
Tumor ST6Gal I activity (mU/mg of protein)	0.57 (0.47, 0.37-0.59)	1.76 (1.21, 0.94-1.93)	0.005
Relative tumor ST6Gal I activity (against non-tumor ST6Gal I activity)	0.46 (0.42, 0.25-0.71)2	2.04 (1.51, 1.35-1.88)	<0.001
Tumor ST6Gal I mRNA level3	1.78 (0.64, 0.24-1.7)	1.51 (1.08, 0.68-2.6)	N.S4
Serum AFP level (ng/mL)	7687 (680, 246-145045)	739 (161, 72-1 197)	N.S.
Serum msAFP percentage (%)	35 (41, 23-45)	18 (13, 11-17)	0.031

¹Mann–Whitney test;

²mean (median, 25^th-75^th percentile);

³group 1: n = 6, group 2: n = 11;

⁴N.S., not significant.