Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping

doi:10.3748/wjg.v11.i33.5129

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World Journal of Gastroenterology

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Gastric Cancer

World J Gastroenterol. Sep 7, 2005; 11(33): 5129-5135
Published online Sep 7, 2005. doi: 10.3748/wjg.v11.i33.5129

Table 1 Karyotypes according to SKY analysis on 10 cell lines derived from advanced gastric cancers

Cell line	Histologic grade¹	Site²	Representative karyotype³
MKN45	Poor	LT	85,XX,del (1) (q32), del (1) (q32), +der (1) t (1;2) (p34;q21), +der (1) t (1;2) (p34;q21), der (2) t (2;22) (p23;q11.2), +del
			(2) (q23), +der (3) t (3;8) (p21.3;q24.1), +der (4) H (9qter→9q22::4p12→4q35::11p11.2→11pter), +der (4) (9qter→9
			q22::4p12→4q35::11p11.2→11pter), +der (5) t (5;8) (q31;q22), +der (5) t (5;8) (q31;q22),
			der (6) t (1;6) (q25;q27), +der (7) t (7;12) (q32;q21), +der (7) t (7;11) (q11.1;q13), +der (7) t (7;11) (q11.1;q13),
			+der (7) t (7;11) (q11.1;q13), +der (7) t (7;9) (q11.2;q34),-8,-8, +9, +10, +der (10) t (8;10) (q23;p15),
			+der (10) t (8;10) (q23;p15), +del (11) (p11.2), +der (12) t (9;12) (p22;q24.1), +der (12) t (10;12) (q11.2;q12), +13, +13,
			+der (14) t (13;14) (q22;p11.2), +der (14) t (13;14) (q22;p11.2), +16, +16, +16, +der (17) t (12;17) (q22;p13),
			+i (17) (p11.1), +der (19) (19pter→19q13.4::7?
			→7?::11q23→11qter), +der (19) (19pter→19q11::8q21.2→8q24.1::20q13.1→20qter), +20, +20, +der (20) t (7;20)
			(q11.2;p12), +der (20) t (7;20) (q11.2;p12), +der (20) t (8;20) (p11.2;q11.2),
			+der (21) t (20;21) (p11.2;q11.2), +der (21) t (12;21)
			(p11.2;q22.3), +22, +22, +mar (6pter→6q21::20p13→20q11.2::7p11.2→7p15::8q22?8q24.1::18q21→18qter)
SNU1	Poor	AS	85,XXYY, +del (1) (p22), +del (1) (p22), -4, -5,-5, -11,-11, -13, -14, -17, -18, +20, +20, +20, +mar
SNU5	Poor	AS	74,XX,der (1) t (1;8) (p36.3;q24.1),der (1) t (X;1) (p11.4;p32), +der (1) t (X;1) (p11.4;p32), +der (2) t (2;11) (p21;q13),
			+der (2) t (2;11) (p21;q13), +2,-3,der (4) t (4;17) (q33;q23), +der (4) t (4;13) (q31;q32), +der (4) (4pter→4q12::13q14
			→13q22::10q24→10qter), +del (5) (q15), +del (5) (p12), +5, +6, der (7) t (7;11) (q36;q13), +del (7) (q32), +del (7) (q32),
			+der (7) (7pter→7q22::11q13→11q23::13q12→13qter), +der (7) t (7;8) (q36;q24.1), +der (8) t (8;13) (q24.1;q14), +
			der (8) t (8;13) (q24.1;q14), +9, +10, +der (10) t (2;10) (p21;q24), +der (10) t (10;15) (q22;q15), +11, +11, +11, +12,
			der (13) (14qter→14q13::13p13→13q32::17q23→17qter),
			+14, +14, +der (15) t (15;22) (p13;q11.2), +16, +i (17q) (p10), +19, +20, +20, +21,-22, +hsr, +dmin
SNU16	Poor	AS	74,XX,del (1) (p13), +hsr (1) (pter→q21::hsr::q21→qter), +2, +3, +6, +6, +6, +del (7) (q22), +del (7) (q22), del (7) (q32),
			der (7) t (7;8) (q22;q24.1),
			+der (8) t (8;11) (q24.1;q13), +9,del (10) (q22), +11, +der (11) (5pter→5p13::11p11.2→11q25::17q23→17qter), +
			12, +12, +13, +14, +der (15) (6pter→6p11.2→::hsr::15p11→15qter), +16, +17, +17, +18, +18, +19, +20, +20,
			+22, 30-50dmin
KMK2	Poor	AS	66,X,del (X) (p11.2) (q22),der (1) (20qter→20q13.1::1p36.1→1q23::8q22→8qter),
			der (1) (17qter→17q21::1p32→1q42::8q24.1→8qter), +der (1) (4qter→4q33::5q35→5q11.2::1p13?→q21::8q
			13→8qter), +der (1) t (1;5) (q21;q32),
			+der (2) t (2;3) (q33;q25),t (3;5) (q25-26.2;q31), +der (3) (3pter→3q24::11q13→11q14::4p12→4pter),
			der (5) del (5) (p12) del (5) (q21), +der (5) (12qter→12q24.1::5p15.1→5q22::13q12→13qter),
			+der (5) t (5;7) (q13;q32), del (6) (q12), del (6) (q12), +del (6) (q25), +der (6) t (6;14) (q21;q22),
			del (7) (q22), der (7) t (7;15) (p22;q13), +der (7) t (6;7) (q15;p15), +der (7) t (7;20) (p11.2;q13), der (8) t (8;17) (p23;q11.2),
			der (9) (Xpter→Xp11.2::8q24.3→8q24.1::9p13→9qter), +der (9) t (3;9) (?;?),
			del (10) (q22), +der (10) (14q?ter→14q?24::10p13→10q21::1p13→1p34::8q24.1→8q24.3::11q13.1→11q13.5
			::7p15→7p22::15q13→15qter),der (12) (12pter→12q22::11q13.3→11q21::3q21→3qter), +der (12) (3pter→
			3p21::12p13→12q24.3::Xq13→Xq22::6p21.3→6pter), +der (12) (17qter→17q11.2::12p11.2→12q24.1::13q12
			→ 13qter),-13,der (13) (13pter→13q14::8q24.1→8q24.3::11q13.3→11q23::12q24.1→12qter),del (14) (q22),
			del (15) (q15), der (16) t (1;16) (p36.1;q22),der (17) (17pter→17q11.2::
			11q13.3→11q21::3q26.2→3qter), +der (17) t (16;17) (q22;q11.2),
			der (18) (22qter→22q11.2::11q21→11q13.3::
			8q24.1→8q22::18p11.2→18qter), +der (18) t (14;18) (q24;q21.3),
			+der (20) t (12;20) (q22;q13.1), +der (20) (20pter→20q11.2::13q12→13q14::8q24.1→8q24.3::11q13.3→11qter),
			+der (20) (20pter→20q11.2::13q12→13q14::8q24.1→8q24.3::11q13.3→11qter), +21,
			+der (22) t (5;22) (p13;q11.2)
KHM14K	Poor	LN	56,X,-Y, +1, +der (3) del (3) (p?) del (3) (q?), +der (3) (9qter?9q13::3q21→3p11::22q11.2→22qter), +der (5) (5qter
			→5p15::3?→3?::22q11.2→22qter),i (5p) (q10), +der (6) (6pter→6q11::5?→5?::17q23→17qter),
			t (8;16) (p23;q22), +der (8) t (8;20) (p11.2;q13.1), der (9) t (9;16) (p13;q12.1), +der (9) t (3;9) (q25;q13), +11,
			der (12) t (5;12) (q13;p13),der (13) t (3;13) (p13;q14), (14;15) (q32;q15), -15, del (15) (q24),
			+der (18) t (3;18) (p21.3;q21.1), +20, +20, +20,der (21) t (15;21) (q11.2-q13;p11.1),-22
GT3TKBU	Ndiffer. mucin-producing	AS	49,der (X) (Xpter→Xq28::HSR::1q32→1qter), +der (X) (Xpter→Xq28::HSR::1q32→1qter),-Y,-1,
			der (1) t (1;8) (p32-36.1;q24.1),der (2) t (2;4) (p12;q12-21),del (3) (p13),del (6) (q25),der (7) t (2;7) (q23;q11.2),-8,i
			(8q), der (9) t (9;10) (p13;q22), der (7;10) (7qter→7p22::13q13→13q11:: 10p11.2→10qter),
			der (10) t (8;10) (q24;p13), +der (10)
			t (10;15) (q11.2;q22),der (11) t (4;11) (q27;q23),der (11) t (1;11) (p13;q13),der (13) t (11;13) (q13;p11.2),
			der (13) t (13;17) (p11.2;p12),der (14) (14qter→14q11.2::3p11→3p26::17q11.2→17q23::3p21→3p23::17q21
			→17qter), der (17) t (8;17) (q24;q11.2), der (17) t (17;19) (p11.2;q13.1), der (17) t (17;19), +del (18) (q21),
			+der (18) t (18;19) (q11.2;q13.1), -19,der (19) t (19;20) (p13.1;p12),
			+der (20) t (18;20) (q11.2;q11.2), +der (20) (8qter→8q24::20p11.2→20q11.2::2q33→2qter),
			+der (20) t (7;20) (q32;q11.2), der (21) t (4;21) (q12;p11.2),-22
MKN28	Moderate	LN	47, X, -X, del (1) (p22), +der (1) t (X;1) (q22-24;q32), del (2) (q13), del (2) (q13), +der (2) t (2;18) (p23;q21.3),
			der (3) del (3) (p13p25) del (3) (q21q25), +der (3) del (3) (p12) del (3) (q21q26.2), -4, -5, -5, -7,
			der (7) t (7;8) (q36;q22), -8, der (8) t (8;10) (p23;q11.2), -10, -13, der (14) t (7;14) (q11.2;q11.2),
			der (14) t (1;14) (q42;q24), +15, +der (16) t (13;16) (q12;q23-24),
			+der (19) t (11;19) (q13;q13.3), der (20) (20pter→20q13.1::8q13→8q24::7q32→7qter),
			+der (20) t (18;20) (q21.1;q11.2), +21, +21
MKN74	Moderate	LT	39, X, +der (X) (15qter→15q11.2::Xp11.2→Xq28::8q24.1→8qter),
			+der (X) t (X;7) (q13;q32), -Y, der (1) (9qter→9q32::1p34→1q32::18q21→18qter), +2, -3,
			der (4) t (4;6) (p12;p21.3), -5, der (7) (7pter→7q32::8q22→8q24.1::9q22→9qter), der (7) t (7;8) (q32;q22), der (8) t
			(8;10) (p23;q22), der (9) t (9;11) (q22;q13), -9, -10, +del (11) (q13), -12, -13,
			der (14) t (9;14) (q13;p11.2), -14, -15, der (16) t (9;16) (q13;q24), +der (16) t (9;16) (q13;q24) del (9) (q22),
			der (18) t (2;18) (?;q23), der (20) t (13;20) (q32;q11.1), -20, -21, -21, der (22) t (10;22) (q24;p11.2),
			+der (22) t (13;22) (q14;p11.2)
MKN1	Adenosqu amous carcinoma	LN	56, X, +inv (X) (p11.2p22.1), -Y, +der (1) t (1;8) (p36.1;q24.1), +der (1) t (1;8) (p36.1;q24.1),
			der (3) t (3;5) (p11;p12), der (3) t (3;20) (q27;q13.1),
			+der (3) t (3;7) (p26;q32.1), -5, -5, -6, +7, +7, +7, +7, del (8) (q24.1), +del (8) (q24.1),
			+del (8) (p11.2), +del (8) (p11.2), -9, -9, +ins (11;17) (q13;q11.2q25), -12, +del (13) (q14q22),
			der (15) t (4;15) (q12;p11.2), -15, +del (16) (q12.1), +del (16) (p11.2), +16, der (17) t (4;17) (p15.2;p11.2),
			der (17) t (4;17) (p15.2;p11.2), del (17) (q11.2), +der (18) t (3;18) (q21;q11.2), del (18) (q11.2),
			del (19) (p13.1), der (19) t (19;21) (q13.1;q11.2), +der (19) t (19;21) (q13.1;q11.2), +del (20) (q11.2),
			+der (20) t (17;20) (q23;q11.2), der (22) t (11;22) (p13;p11.2)

¹Poor: poorly differentiated adenocarcinoma; Moderate, moderately differentiated adenocarcinoma.

²ST: stomach; LT: metastatic liver tumor; AS: ascitic fluid; LN: lymph node. 3Representative karyotypes are defined based on G-banding and SKY findings, and described according to ISCN1995.

Table 2 Karyotypes according to SKY analysis on 7 patients with advanced gastric cancer and carcinomatous peritonitis

Case number.	Age/Sex	Origin1	Histologic grade2	G-banding and SKY
1	52/M	AS	Poor	89, XX, der (1) t (1;13) (q44;q14), t (1;2) (p36.3;p11.1), +der (1) t (1;2), +der (1) t (1;8) (p22;q24),
				+der (1) t (1;8) (p22;q24), +der (1) t (1;12) (q32;q13) del (1) (p32), +2, +2, +3, +4, +4, +del (5) (q13),
				+6, +6, +6, +7, +7, +7,
				der (8;8) (8pter→8q24.1::8p23→8q24.1::17q23→17qter), +der (8) t (8;11) (q24.1;q13), +del (8) (p11.2),
				+del (8) (p11.2), +9, +9, +i (9q), del (10) (q24), +der (10) t (8;10) (q24.1;q11.2),
				+der (10) t (8;10) (q24.1;q11.2), +inv (10) (p15.1q21), +11, +11, +12, +14, i (15q),
				i (15q), +16, +16, +17, del (18) (q11.2), +der (18) t (10;18) (p11.2;p11.2),
				+der (18) t (10;18) (p11.2;p11.2), +der (18) t (10;18) (q22;q21), +der (18) t (10;18) (q22;q21), +19, +19,
				+20, +20, +20, +20, +20, +20, -21, -21, +22
2	72/M	AS	Poor	47, XY, +X, -3, del (13) (q14), +mar
3	63/M	AS	Poor	54, der (X) t (X;3) (q24;q21), Y, +2, +del (4) (q21), +der (4) (4p15→4q12::17q11.2→17qter), +del (5) (q13),
				der (6) t (Y;6) (q11.2;p21.1), t (7;16) (q36;q22), der (11) t (9;11) (q13;q13), +del (11) (q13), +11, del (12)
				(p11.2), der (13) t (8;13) (q13;q14), +15, +16, -21, -21, +22, +22
4	56/M	AS	Signet	46, X, -Y, +der (1) t (?;1;?) (?::1p13→1q21::?), t (2;20;8) (p11.2;q11.2;q24.1),
				t (2;20;8) (p11.2;q11.2;q24.1), +2, +2, der (3) (3qter→3p13::7?→7?::11q13→11qter), del (3) (p23) (q25),
				-4, -4, +del (5) (q13), +del (5) (q11.2), del (6) (q11),
				+der (6) (6p21.1→6q21::18q11.2→18qter), dic (7;11) (q11.2;p15), del (9) (p11), del (10) (p11.2),
				del (10) (p11.2), +10,
				der (11) t (?;11;?) (?::11p13→11q23::?), der (11) (2pter→2p11.2::11q12→11p11.2::7q11.2→7q32::
				17q23→17qter),
				der (11;20) (20pter→20q11.2::11p13→11q23::11q13→11q14::7q31→7q36::13q14→13qter),
				del (12) (q13), del (12) (q22), der (13) t (X;13) (p11.2;p11.2), der (13) (3pter→3p13::13p13→13q14::18q21
				→18qter), -14, -15, del (16) (q22), add (17) (p11.2), add (18) (q21.3), -18, -19, +20,
				der (21) t (17;21) (q23;q22), der (21) (7pter→7p11.2::21p13→21q22.1::hsr::21q22.1→21qter), -22
5	55/M	AS	Signet	50, add (X) (p22.3), Y, +8, +9, +16, +18
6	37/M	AS	Poor	69, der (X) (Xpter→Xq22::18q11.2→18q21::4q31.1→4qter),
			Signet	der (X) (Xpter→Xq22::18q11.2→18q21::4q31.1→4qter), -Y, +der (1) t (1;12) (q25;q13),
				+del (1) (p22), del (2) (q23), del (2) (q23), +der (2) t (1;2) (q23;q21), +der (2) t (1;2) (q23;q21),
				del (3) (p21), +del (3) (p13), +del (3) (q11.2), +5, +5, der (6) t (6;18) (q12;q11.2), -6, +7, +7, +der (8)
				(5qter→5q31::8p11.2→8q24.1::13q14→13qter),
				+der (8) (5qter→5q31::8p11.2→8q24.1::13q14→13qter), +der (10) t (4;10) (q12;q22),
				+der (10) t (4;10) (q12;q22), +der (11) t (7;11) (q22;q23),
				+der (11) t (11;17) (q25;q11.2), +12, der (13) t (6;13) (p21.1;p11.2), -13, der (14) t (14;17) (p11.2;q11.2),
				der (14) t (14;17) (p11.2;q11.2), +15, +15, +16, +16, der (17) t (X;17) (q22;q11.2),
				der (17) t (X;17) (q22;q11.2), +18, +18, +20, +21, +der (21) t (X;21) (q22;p11.2)
7	73/F	AS	Poor	67, X, del (X) (q26), der (1) (1qter→1p22::11?→11?::8?→8?::22q11.2→22qter), der (1) (1?→1?::15?
			Signet	→15?::1?→1qter), der (1) (9pter→9p13::1p12→1q32::9q22→9qter), -2, -5,
				+der (7) t (7;9) (q32;q22), +der (7) t (7;9) (q32;q22), +der (7) t (7;20) (q22;q11.2),
				+der (7) t (7;20) (q22;q11.2), t (8;14) (q13;p13), +der (8) t (8;14), t (6;8) (p11.2;p21), +8, -9,
				+der (10) t (2;10) (p13;q24), +11, -12, +der (14) (20qter→20q13.1::
				14p11.2→14q24::11q13→11qter),
				+der (14) t (3;14) (p21;q13), +14, +15, +16, +17, +18, +18, +18, +18,
				+der (18) t (18;20) (q11.2;q11.2), +19, +20, +21, +21, +22, +der (22) t (1;22) (p22;p11.2)

¹AS: ascitic fluid. ²Poor: Poorly differentiated adenocarcinoma; Signet: signet ring cell carcinoma.

Table 3 Recurrent breakpoints and partners in gastric cancer cells defined by SKY analysis

Translocation	Number of	Candidate	Partner breakpoints involved in chromsomal translocations or deletions1
breakpoint	breakpoints	genes	Common	Single
8q24.1	30	MYC	11q13 [3], 13q14 [4]	1p22, 1p32-36.1, 1p34, 1p36.1, 1p36.3, 1q42, 2p11.2, 3p21.3, 7q22,
				7q32, 7q36, 8p23, 9p13, 9q22, 10p13, 10q11.2, 17q11.2, 17q23,
				18q21, 20p11.2, 20q11.2, 20q13.1, Xq28, deletion
11q13	26	FGFR4	8q24.1 [3], 8q24.3 [3],	1p13, 2p21, 7p15, 7q11.1, 7q22, 7q36, 7?, 9q13, 9q22, 11q23, 12q22,
				13p11.2, 14q24, 17q25, 19q13.3
		FGF3	3q24-25 [2], 17q11.2 [2],
		CCND1	deletion [2]
20q11.2	14	Unknown	18q11.2 [2]	2p11.2, 2q33, 7p11.2, 7q22, 7q32, 8p11.2, 8q24, 11p13, 13q12,
				17q23, 18q21.1, deletion
1p32-36.3	12	RUNX3	8q24 [4]	2p11.1, 2q21, 9q32, 16q22, 17q21, 20q13.1, Xp11.4, deletion
13q14	12	RB	8q24.1 [3]	1q44, 3p13, 4q12, 7q36, 8q13, 13q22, 18q21, 22p11.2, deletion
17q11.2	12	ERBB2	11q13 [2]	3p26, 4q12, 8p23, 8q24, 11q25, 12p11.2, 14p11.2, 16q22, Xq22, deletion
7q32	11	MET	deletion [2]	3p26, 5q13, 8q22, 8q24, 9q22, 12q21, 17q23, 20q11.2, Xq13
18q21	11	BCL2	None	1q32, 2p23, 3p21.3, 4q31.1, 8q24.1, 10q22, 13q14, 14q24, 20q11.2, deletion
17q23	10	Unknown	11q25 [2]	3p21, 4q33, 5?, 7q32, 8q24.1, 13q32, 20q11.2, 21q22
10q22	9	KSAM	deletion [2]	4q12, 6p25, 8p23, 9p13, 15q15, 15q22, 18q21
18q11.2	9	Unknown	20q11.2 [2],deletion [2]	3q21, 6q12, 6q21, 19q13.1, Xq22

¹The number of breaks are indicated.

Citation: Yamashita Y, Nishida K, Okuda T, Nomura K, Matsumoto Y, Mitsufuji S, Horiike S, Hata H, Sakakura C, Hagiwara A, Yamagishi H, Taniwaki M. Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping. World J Gastroenterol 2005; 11(33): 5129-5135
URL: https://www.wjgnet.com/1007-9327/full/v11/i33/5129.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i33.5129