Helicobacter Pylori
Copyright ©The Author(s) 2005.
World J Gastroenterol. Aug 21, 2005; 11(31): 4782-4787
Published online Aug 21, 2005. doi: 10.3748/wjg.v11.i31.4782
Table 1 Baseline characteristics
H pylori-positive (n = 49)H pylori-negative (n = 33)
Mean age, ys (range)49.9 (25-72)49.6 (28-78)
Male/female24/2514/19
Smoker17 (34.7%)12 (36.4%)
Alcohol drinker16 (32.7%)10 (30.3%)
Body mass index (range)24.4 (17.1-29.0)23.7 (16.4-28.8)
Table 2 Plasma and gastric juice HBD-1 and HBD-2 levels and gastric juice IL-1β and -8 concentrations
H pylori-positive (n = 49)H pylori-negative (n = 33)P
Plasma
HBD1 -1 levels (ng/mL)10.1±0.99.6±1.8NS
HBD-2 levels (pg/mL)276.2±61.0257.2±56.0NS
Gastric juice
HBD-1 levels (pg/mL)384.2±101.5357.9±79.6NS
HBD-2 levels (pg/mL)230.3±77.4118.1±87.7<0.0005
Interleukin 1β levels (mg/mL)53.6±16.95.3±4.4<0.05
Interleukin 8 levels (pg/mL)17.9±3.18.6±1.7<0.005
Table 3 Correlation coefficients between gastric human-β-defensin 2 levels and each histological parameter
Correlation coefficientP
Antrum
Activity0.048NS
Chronic inflammation0.258NS
Glandular Atrophy0.148NS
Intestinal Metaplasia-0.063NS
H pylori density0.011NS
Corpus
Activity0.499<0.005
Chronic inflammation0.341<0.05
Glandular Atrophy0.294NS
Intestinal Metaplasia0.081NS
H pylori density0.237NS
Table 4 Gastric juice HBD-2 and IL-1β and -8 levels before and after anti-H pylori therapy
Successful eradication of H pylori (n = 10)
Failed eradication (n = 4)
Before therapyAfter therapyPBefore therapyAfter therapyP
Gastric juice
HBD1-2 levels (pg/mL)182.2±57.6210.1±66.4NS137.4±65.2112.9±79.3NS
Interleukin 1β levels (pg/mL)17.7±10.20.5±0.3<0.0588.5±80.964.7±64.1NS
Interleukin 8 levels (pg/mL)22.3±2.112.8±1.8<0.00518.1±6.118.6±4.5NS