Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats

Table 1 Clinical findings

Time (d)	Gross bleeding		Diarrhea
	NS	Anti-ECP	NS	Anti-ECP
1	0	0	0	0
2	0	14.3	14.3	14.3
3	14.3	0	14.3	14.3
4	0	0	0	0
5	14.3	0	28.6	14.3
6	42.9	14.3	28.6	0
7	42.9	28.6	0	0

Data are percentage of animals (n = 7).

Table 2 Effects of anti-ECP antibody on ulcer index and colon length (mean±SE, n = 7)

Group	Ulcer index (%)1	Colon length (cm)
DSS+normal serum	61.1±25.5	12.3±0.6
DSS+anti-ECP	43.1±29.4a	13.4±0.4b

¹Ulcer length/circumference length´100.

^aP<0.05 vs DSS+normal serum.

^bP<0.01 vs DSS+normal serum.

Table 3 Effects of anti-ECP antibody on the Ki-67-positive cells in the regenerative surface of colonic epithelium at d 7 after DSS treatment (mean±SE, n = 7)

Group	Ki-67-positive cells1
DSS+normal serum	14.0±6.5
DSS+anti-ECP	21.3±10.4a

¹Number of Ki-67-positive cells/circumference.

^aP<0.05 vs DSS+normal serum.