Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma

Table 1 Relationship of the expression of survivin and clinicopatho-logical factors of HCC

	n	Survivin		P
		Positive (n)	Percent (%)
Tissue				< 0.01
Cirrhosis	38	3	7.9
HCC	38	23	60.5
Age (yr)				> 0.05
< 60	31	19	61.3
≥ 60	7	4	57.1
Sex				> 0.05
Male	33	21	63.6
Female	5	2	40
Size (cm)				> 0.05
≥ 5	17	12	70.6
< 5	21	11	52.4
Differentiation				> 0.05
Moderate to well	16	9	56.3
Poor	22	14	63.6
Metastasis				< 0.05
Positive	14	12	85.7
Negative	24	11	45.8

Table 2 Expression of survivin and VEGF protein in HCC tissues

	VEGF		P
	Positive	Negative
Survivin			<0.01
Positive	18	5
Negative	3	12

Table 3 Coincident expression of survivin and VEGF protein in HCC or liver cirrhosis tissues

	HCC group	Cirrhosis group	P
	(n = 38)	(n = 38)
Survivin	3229.3 ± 1383.2	562.6 ± 226.5
			< 0.01
VEGF	1134.8 ± 862.2	445.4 ± 322.6

Table 4 Correlation between HCC metastasis and expression of survivin and VEGF protein

	Metastasis group	Non-metastasis group	P
	(n = 14)	(n = 24)
Survivin	3841.4 ± 1061.2	1253.8 ± 725.3	< 0.01
VEGF	1388.6 ± 652.4	1081.3 ± 773.5	< 0.01