Expression of sialyl Lewisa relates to poor prognosis in cholangiocarcinoma

Table 1 Expression of sLe^a in tumor tissues of CCA patients.

Expression of sLea	Tumor type		Total
	Mass-forming	Periductal infiltraing
0	37	7	44
1+	7	7	14
2+	8	6	14
3+	25	13	38
Total	77	33	110

Table 2 Correlation between expression of tissue sLe^a and clinicopathologic features.

		Expression of sLea				P
		0	1+	2+	3+
CCA type
Mass-forming		37	7	8	25	0.041
Periductal-infiltrating		7	7	6	13
Histology type
Papillary		2	3	1	8	0.029
Well differentiated		8	5	6	14
Moderately differentiated		8	3	4	5
Poorly differentiated		19	2	0	9
Squamous/adenosquamous		7	1	3	2
Vascular invasion	- No	13	8	9	11	0.03
	- Yes	31	6	5	21
Neural invasion	- No	27	8	4	14	0.054
	- Yes	17	6	10	24
Lymphatic invasion	- No	9	5	2	9	0.56
	- Yes	35	9	12	29

Table 3 Significant prognostic factors contributing to disease-free survival by multivariate Cox’s proportion-hazard regression model.

Variable	Coefficient	SE	Hazard ratio	P
Age (55 vs >55 yr)	-0.013	0.011	0.987	0.257
Sex (male vs female)	0.294	0.25	1.342	0.239
CCA type (mass-forming vs periductal-infiltrating)	0.44	0.322	1.552	0.173
Histology
Papillary	-0.83	0.471	0.436	0.078
Well differentiated	-0.891	0.402	0.41	0.027
Moderately differentiated	-0.736	0.462	0.479	0.111
Poorly differentiated	-0.356	0.405	0.701	0.379
Squamous/adenosquamous	0.264	0.756	1.302	0.727
Vascular invasion (present vs absent)	-0.234	0.272	0.791	0.39
Neural invasion (present vs absent)	-0.362	0.247	0.696	0.143
Lymphatic invasion (present vs absent)	0.053	0.313	1.055	0.865
Tissue sLea (present vs absent)	0.834	0.26	2.302	0.001