Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells

Table 1 Results of cell viability assay (%)¹.

	HT1080	KYSE510	MG63	HELF
Syl-155	40.79	80.61	85.59	87.59
Syc-40	91.23	88.65	90.70	92.51

¹The percentage shown was the VR of three tumor cell lines and one normal cell line after treatment with non-peptidic small compound (syl-155) or negative control compound (syc-40)[21] for 3 d at the concentration of 10 μg/mL. The results were shown as the mean value of three different experiments.

Table 2 Changes in cell cycle distribution (%)¹.

	Negative control	DMSO	Syl-155
			24 h	48 h	72 h
G0/G1	54.1	49.8	60.6	60.0	63.5
S	34.1	37.1	30.4	23.9	27.6
G2/M	11.8	13.1	9.0	16.1	8.9

¹The percentage shown is the distribution of cell cycle in HT1080 cells.