Effects of augmentation of liver regeneration recombinant plasmid on rat hepatic fibrosis

Table 1 Histological grading of hepatic fibrosis.

Group	n	Grade 0	Grade 1	Grade 2	Grade 3	Grade 4
N	10	10	0	0	0	0
Mc	9	0	0	0	4	5
Cola	10	0	3	3	2	2
ALR1a	9	0	2	4	1	2
ALR2a	10	1	3	3	2	1

^aP<0.05 vs model control group;

^cP<0.05 vs normal control group.

Table 2 Serum content of ALT, AST (mean±SD).

Group	n	ALT(u/L)	AST(u/L)
N	10	69.88±10.16	134.25±21.63
M	9	108.67±16.69c	201.22±22.85c
Col	10	73.20±12.25a	182.10±48.11a
ALR1	9	88.56±11.18a	165.33±22.21a
ALR2	10	78.40±14.60a	160.90±23.99a

^aP<0.05 vs model group;

^cP<0.05 vs normal control group.

Table 3 Serum content of HA, LN, PCIII and IV (mean±SD).

Group	n	HA (µg/L)	LN (µg/L)	PCIII (µg/L)	IV (µg/L)
N	10	338.67±48.24	33.71±14.53	10.17±2.78	36.80±15.04
M	9	435.91±40.31c	62.50±9.72c	18.13±7.11c	125.00±45.06d
Col	10	357.90±90.99a	40.98±13.74a	11.29±4.42a	37.78±8.89b
ALR1	9	327.43±111.26a	36.56±10.01a	12.60±8.80a	41.29±23.86b
ALR2	10	319.29±73.91a	36.04±8.89a	5.74±2.14aeg	38.38±16.36b

^aP<0.05 vs model control group;

^bP<0.01 vs model control group;

^cP<0.05 vs normal control group;

^dP<0.01 vs normal control group;

^eP<0.05 vs Col group;

^gP<0.05 vs ALR₁ group.

Table 4 Expression of I, III and IV collagen and TIMP-1 and level of TIMP-1 mRNA in relation to β-actin (mean±SD).

Group	n	I collagen	III collagen	TIMP-1	TIMP-1 mRNA/β-actin
N	10	3.23±1.02	2.92±1.13	0.16±0.06	0.49±0.09
M	9	10.83±3.58d	10.25±2.61d	0.53±0.12d	1.36±0.11d
Col	10	7.10±1.76b	5.81±1.86b	0.30±0.05b	0.77±0.16b
ALR1	9	6.94±1.42b	7.18±1.95a	0.39±0.05b	0.89±0.08b
ALR2	10	5.80±1.66b	4.50±1.67bg	0.20±0.06bfh	0.65±0.11bh

^aP<0.05 vs model control group;

^bP<0.01 vs model control group;

^dP<0.01 vs normal control group;

^fP<0.01 vs Col group;

^gP<0.05 vs ALR₁ group;

^hP<0.01 vs ALR₁ group.