Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral administration of RS-propranolol in Chinese Han subjects

Table 1 Excretion amounts of S-(-)- and R-(+)-propranolol glucuronide and the ratio of S-/R-propranolol glucuronide in the urine of Chinese Han volunteers (n = 16).

Time (h)	0–1	1–2	2–3	3–4	4–6	6–8	8–10	10–12	12–24
S-(µmoL)	0.239±0.13	1.08±0.34	1.16±0.31a	0.81±0.27b	1.01±0.19b	0.54±0.21b	0.28±0.11b	0.20±0.09b	0.32±0.12b
R-(µmoL)	0.328±0.17	0.98±0.29	0.73±0.20	0.34±0.12	0.30±0.08	0.13±0.08	0.06±0.03	0.04±0.03	0.04±0.04
S-/R-	0.729	1.1	1.59	2.38	3.37	4.15	4.67	5	8

Differences in mean values between S-(-)- and R-(+)-propranolol glucuronide were significant;

^aP<0.05,

^bP<0.01 vs R-(+)-propranolol glucuronide.

Table 2 Main pharmacokinetic parameters of S-(-)- and R-(+)-propranolol glucuronide after an oral dose in Chinese Han healthy volunteers (n = 16).

Glucuronide	k (h-1)	t1/2 (h)	Tmax(h)	[Xu]0→24(mmoL)
S-PL	0.195±0.04b	3.56±0.7b	2.21±0.45b	5.65±0.98b
R-PL	0.283±0.06	2.45±0.5	1.75±0.33	2.95±0.62

Differences in mean values between S-(-)- and R-(+)-propranolol glucuronide were significant;

^bP<0.01 vs R-(+)-propranolol glucuronide.