Copyright
©The Author(s) 2004.
World J Gastroenterol. Feb 15, 2004; 10(4): 567-572
Published online Feb 15, 2004. doi: 10.3748/wjg.v10.i4.567
Published online Feb 15, 2004. doi: 10.3748/wjg.v10.i4.567
Table 1 Insulin production in STZ-induced diabetic mice after insulin vector treatment (mean ± SD)
| Serum insulin Level(µU/ml) | pCMV-mhINS | pT-mhINS + pCMV-SB | Diabetic control | Normal control |
| 1 day after treatment | 113.1 ± 20.6 | 97.2 ± 14.4 | 5.2 ± 0.3 | 10-50 |
| 7 days after treatment | 4.8 ± 1.3 | 33.3 ± 10.2 | - | - |
| 14 days after treatment | 3.4 ± 0.2 | 12.7 ± 4.6 | - | - |
Table 2 Quantity of mhINS mRNA in mouse liver after plasmid infusion (mean ± SD)
| Quantity of mRNA(pg) | pCMV-mhINS | pT-mhINS + pCMV-SB | Diabetic control |
| 7 days after treatment | 0.21 ± 0.14 | 3.41 ± 1.48 | 0 |
| 14 days after treatment | 0.13 ± 0.04 | 1.24 ± 1.06 | 0 |
Table 3 Insulin-positive cells in mouse liver after plasmid infusion (mean ± SD)
| Positive cells | pCMV-mhINS | pT-mhINS + pCMV-SB | Diabetic control |
| 7 days after treatment | 6.3 ± 2.3 | 19.0 ± 5.7 | 0 |
| 14 days after treatment | 2.3 ± 0.9 | 9.3 ± 2.4 | 0 |
- Citation: He CX, Shi D, Wu WJ, Ding YF, Feng DM, Lu B, Chen HM, Yao JH, Shen Q, Lu DR, Xue JL. Insulin expression in livers of diabetic mice mediated by hydrodynamics-based administration. World J Gastroenterol 2004; 10(4): 567-572
- URL: https://www.wjgnet.com/1007-9327/full/v10/i4/567.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i4.567