L-arginine-induced experimental pancreatitis

Table 1 Induction of pancreatitis: differences in methods

Dose of L-Arginine	Reference
Single dose
500 mg/100 g bm ip.	Mizinuma et al. 1984, Kishino et al. 1984, Tani et al. 1990, Shields et al. 2000, Kihara et al. 2001, Tachibana et al. 1997, Tashiro et al. 2001
450 mg/100 g bm ip.	Tashiro et al. 2001
400 mg/100 g bm ip.	Tashiro et al. 2001, Rakonczay et al. 2002
300 mg/100 g bm ip.	Tashiro et al. 2001, Rakonczay et al. 2002
250 mg/100 g bm ip.	Pozsar et al. 1997
200 mg/100 g bm ip.	Tashiro et al. 2001
Double dose
2 × 250 mg/100 g bm ip.	Takacs et al. 1996, Varga I. et al. 1997, Toma et al. 2000, Czako et al. 2000, Czako et al. 2000, Czako et al. 2000, Takacs et al. 2002, Toma et al. 2002
2 × 230 mg/100 g bm ip.	Takacs et al. 2002
2 × 200 mg/100 g bm ip.	Hegyi et al. 1997, Hegyi et al. 1999, Hegyi et al. 2000, Takacs et al. 2001
Multiple dose
350 mg/100 g bm ip. daily from 1 to 4 wk	Weaver et al. 1994
a single 500 mg/100 g bm ip. and triple 250 mg/100 gbm ip. (d 4, 7, 10)	Delaney et al. 1993

Table 2 Changes of inflammatory mediator levels in Arg-induced acute pancreatitis

Mediator	Dose of Arg/100 g bm	Effect	Reference
MDA	2 × 250 mg	↑	Czakó et al., 1998
NSG, MDA	300 mg	↑	Rakonczay et al., 2003
Protein carbonyl	300 mg	↑	Rakonczay et al., 2003
Mn-, Cu, Zn-SOD	2 × 250 mg	↓	Czakó et al., 1998
Catalase	2 × 250 mg	↓	Czakó et al., 1998
glutathione peroxidase	2 × 250 mg	↓↑	Czakó et al., 1998
Serum TNF-α, IL-6	2 × 250 mg	↑	Czakó et al., 2000
Serum TNF-α, IL-1, IL-6	2 × 230 mg	↑	Rakonczay et al., 2002
Pancreatic IL-1β	300 and 400 mg	↑	Rakonczay et al., 2003
Pancreatic TNF-α	300 and 400 mg	↑	Rakonczay et al., 2003
Pancreatic cNOS	2 × 250 mg	↓↑	Takács et al., 2002
Pancreatic iNOS	2 × 250 mg	↑	Takács et al., 2002
CCK	2 × 250 mg	↑	Czakó et al., 2000

↓: Decreased activity, ↑: Increased activity, Arg: L-arginine, MDA: Malondialdehyde, NSG: Nonprotein sulfhydryl group, SOD: Superoxide dismuthase, TNF: Tumor necrosis factor, IL: Interleukin, CCK: Cholecystokinin-octapeptide.