Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multidrug-resiatant human colon carcinoma LoVo/5-FU cells

Table 1 Effect of wild-type p53 on LoVo/5-FU sensitivity to 5-flurouracil

Cell lines	IC50 (µg/mL)	Resistant time	Reverse time
LoVo cells	0.82
LoVo/5-FU cells	7.37	8.988
LoVo/5-FU cells + wild-type p53	1.48b	1.804	4.982

^bP < 0.01 compared with LoVo/5-FU cell control group.

Table 2 MDR1 expression in different cell lines

	Lane 1	Lane 2	Lane 3	Lane 4
MDR1/β-actin	1.26	1.19	0.42	0.33

Table 3 MDR1 expression of LoVo/5-FU cells on different day after dealing with Ad-p53

Time/d	2	3	4	5	6
MDR1/β-actin	1.22	1.24	1.06	0.86	0.42