Blockage of transforming growth factor β receptors prevents progression of pig serum-induced rat liver fibrosis

Table 1 Effects of transfected plasmid on the content of hepatic hydroxyproline and deposition of collagen types I and III (mean ± SD)

Group	Number	Hydroxyproline (mg/g liver)	Collagen I	Collagen III
Disease control group	10	0.296 ± 0.026d	1209.44 ± 116.60d	1175.14 ± 121.44d
Antisense TβR II group	10	0.167 ± 0.009bd	650.26 ± 51.51bd	661.58 ± 55.28bd
Antisense TβR I group	10	0.169 ± 0.015d	669.90 ± 50.67d	657.29 ± 49.48d
pcDNA3 control group	10	0.284 ± 0.025d	1205.70 ± 110.11d	1149.89 ± 91.61d
Normal control group	6	0.128 ± 0.004	449.33 ± 35.95	421.15 ± 20.15

^bP < 0.01 vs disease control group and pcDNA3 control group,

^dP < 0.01 vs normal control group.

Table 2 Pathological grade of liver fibrosis at the 8th week

Group	Grade							Total
	0	I	II	III	IV	V	VI
Disease control groupd	0	0	0	1	4	4	1	10
Antisense TβR II groupdb	1	7	2	0	0	0	0	10
Antisense TβR I groupdb	1	6	3	0	0	0	0	10
pcDNA3 control groupd	0	0	0	1	5	3	1	10
Normal control group	6	0	0	0	0	0	0	6

^bP < 0.01 vs disease control group and pcDNA3 control group,

^dP < 0.01 vs normal control group.