Risk factors of development of gut-derived bacterial translocation in thermally injured rats

Table 1 Univariate analysis of suspected factors for development of bacterial translocation

		BT1 (n = 69)	Non-BT2 (n = 59)	t- or z-value	P-value
Endotoxin (EU/mL)		0.158 ± 0.0447	0.110 ± 0.0348	6.443	0.000
Microbe flora3
	Fungi	3.80 ± 0.8	3.2 ± 0.7	2.859	0.005
	E. coli	4.90 ± 1.0	4.0 ± 1.0	5.076	0.000
	Bifidobacteria	6.10 ± 0.6	7.3 ± 0.5	6.967	0.000
SigA (μg/mg protein)		55.78 ± 9.81	87.51 ± 10.69	16.857	0.000
Ileo-lesion score		4 (2-6)	2 (0-4)	9.178	0.000
IL-6 (pg/mL)		871 ± 588	499 ± 308	4.125	0.0001

¹Animals with bacterial translocation;

²Animals without bacterial translocation;

³Mucosal micro-flora (log₁₀ CFU/g tissue).

Table 2 Correlation analysis of data associated with bacterial translocation

	X1	X2	X3	X4	X5	X6	X7
X1	1.0000
X2	0.7166	1.0000
X3	0.4586	0.3847	1.0000
X4	-0.5135	-0.4029	-0.5516	1.0000
X5	-0.5434	-0.4416	-0.4795	0.7363	1.0000
X6	0.4834	0.3369	0.3663	-0.6676	-0.7312	1.0000
X7	0.4807	0.3679	0.2550	-0.3772	-0.3772	0.3549	1.0000

X1: endotoxin levels (EU/mL), X2: counts of fungi (log₁₀ CFU/g tissue), X3: counts of E. coli (log₁₀ CFU/g tissue), X4: counts of bifidobacteria (log₁₀ CFU/g tissue), X5: mucous sIgA levels (μg/mg protein), X6: ileal lesion score, X7: IL-6 levels (pg/mL).

Table 3 Independent predictors of bacterial translocation evaluated by multivariate analysis

	Coefficient	Odds ratio (95% CI1)	z-value	P-value
X62	3.8182 ± 1.1022	45.52 (5.25-394.80)	3.464	0.001
X43	-3.2424 ± 1.2757	0.039 (0.003-0.48)	-2.542	0.011
Constant	9.9220 ± 8.7435		1.135	0.256

¹Confidence interval;

²Ileal lesion score;

³Counts of bifidobacteria (log₁₀ CFU/g tissue).