Inflammatory pseudotumor of the liver: 13 cases of MRI findings

Abstract

Key Words: granuloma, plasma cell/diagnosis, liver diseases/diagnosis, liver/pathology, magnatic resonance imaging

INTRODUCTION

Inflammatory pseudotumor of the liver, a rare benign lesion, is often confused with the malignant tumors. Until 1998, less than 80 cases had been reported in the world[1,2]. The accuracy of the pre-surgical diagnosis was low[3,4], and very few materials on the diagnosis using dynamic MRI were reported[5-7]. We collected thirteen cases of inflammatory pseudotumor of the liver were collected and proved by pathology with MRI studies. Our purpose is to describe and analyze the MRI findings of this lesion and find out the valuable signs suggesting the diagnosis so as to avoid unnecessary operations.

MATERIALS AND METHODS

Thirteen cases collected from September 1995 to December 2000 in our hospital (9 men and 4 women aged from 31-58 years, 41 years in average). More than half of the cases had no symptoms, and the others complained of upper abdominal discomfort, only three cases had fever of unknown causes. AFP and other liver lab testing were normal.

All of 13 cases underwent MR examinations with 1.5T Signa scanner (GE Medical Systems Milwaukee, WI), including T₁WI (TR/TE = 500-700 ms/14-16 ms), T₂WI SE sequence (TR/TE = 2000-4000 ms/60-90 ms) and FMPSPGR dynamic enhanced MRI(Matrix 256 × 128, thickness 7 mm, gap 3 mm, TR/TE Flip Angle = 100-150 ms/1.5-4.5 ms/60-90°). Four repeated acquisitions were obtained at 25-30, 60, 90 and 180 s respectively following power injection of 15-20 mL (0.15 mmol·kg^-1) of Gd-DTPA (gadopentetic dimeglumine, Magnevist, Shering Pharmaceutical Ltd.) via an antecubital vein.

The MRI imagings of all cases were read and analyzed by two experienced doctors. Comparisons were made between preoperative diagnosis and results of surgical pathology.

RESULTS

A total of 16 lesions were identified by surgical pathology in the 13 cases, including three lesions in 1 case and single one in 12 cases. The size of the lesions was 0.8-3 cm in diameter (2.1 cm in average). The shape of the lesions was also variable, being round, ovoid, lobular (seen in coalescence of small focus) and irregular.

On SE sequence T₁WI, 6 of 16 lesions were isointense (Figure 1A), the other 10 lesions were slightly hypointense (Figure 2A). On SE sequence T₂WI, 6 of 16 lesions were slightly hyperintense (Figure 2B), the other 10 lesions were nearly equal intensity of signal to that of normal parenchyma (Figure 1B). The lesions discovered on SE sequence MRI were not well defined and the conspicuity between the lesions and the parenchyma were much less than that seen on dynamic MRI imaging of portal venous and delayed phases.

Figure 1 Inflammatory pseudotumor of the liver in the right posterior lobe. A: SE T₁WI and B: SE T₂WI could not show any lesions. C: A hypointense lesion could be found in the right lobe(arrow), there is no enhancement in early arterial phase of dynamic contrast MRI. D: portal venous phase of dynamic contrast MRI showed the enhanced septum(arrow).

Figure 2 Inflammatory pseudotumor of the liver in the right posterior lobe. A: SE T₁WI showed a hypointense lesion(arrow). B: SE T₂WI showed the lesion was slightly and inhomogeneously hyperintense(arrow). C: There is no enhancement in early arterial phase of dynamic contrast MRI, the edge of the lesion was not clear(arrow). D: portal venous phase of dynamic contrast MRI showed the punctual core in the center and peripheral enhancement (arrow).

On dynamic enhanced MRI, none of the lesions showed enhancement in the dominant arterial phase (Figure 1C, Figure 2C). Therefore, the lesions were not seen clearly in this phase. On the contrary, all the lesions were well defined in the portal venous phase or/and the delayed phase. In these phases, the following appearances could be found: ① peripheral enhancement of the lesion (12/16, 75%) (Figure 2D). ② Small nodular enhancement (6/16, 37.50%), located in the central area of the lesions like core (Figure 2D), or near the marginal area of the lesions which we described as stalactite. ③ Septum within the lesions which could be linear or thick and irregular in appearance were seen in 8 (50%) of 16 lesions, and enhanced in the portal venous phase or/and delayed phase (Figure 1D). ④ All findings on dynamic MR imaging were seen overlapped.

DISCUSSION

Correlation of pathology with MR imaging findings

Inflammatory pseudotumor of the liver is a rare benign disease, occasionally discovered by US, CT and MRI[5-9]. The etiology has not yet been very clear, and may be related to infection and immunogical compromise. Fibroblastic proliferation and chronic inflammatory cell infiltration constitute the characteristic features of the disease[3,10]. The mass is surrounded by the fibrocollageous stroma rich with capillary vessels, which may explain the peripheral enhancement in portal and delayed phases scans in the majority of cases due to the extravascular accumulation of contrast medium. Within the mass, there are less inflammatory cell components and more coagulative necrosis, so on SE T₂WI, most of the lesions were nearly equal intensity of signal to that of normal parenchyma because of coagulative necrosis containing less free water. These are the characteristics of inflammatory pseudotumor of the liver. Six lesions showed slightly hyperintense on SE T₂WI, because of more inflammatory cell infiltration within the lesions. The larger area consisted of coagulative necrosis and cell components in the central region does not enhance as fibrosis in later phase and appears heterogeneous. It was not enhanced in early arterial phase since the lesion had no direct hepatic arterial blood supply.

Detection and differential diagnosis

Most of the lesions could be detected by sonography in our group, but as it was hard to be characterized, color Doppler ultrasound became mandatory supplementary modality, which could recognize the presence or absence of arterial blood flow to help determine the nature of the lesions.

SE sequence of MRI had more limitations in detection of the lesions since the difference of signal intensity was not conspicuous between the lesion and parenchyma on T₁WI as well as on T₂WI. Six of 16 lesions in this group were isointense on T₁WI and 10 of 16 lesions were also isointense on T₂WI, and the others had only slight or moderate difference with the normal hepatic parenchyma. So, contrast enhanced MRI was very important to avoid potentially missing detection of small lesions and it is very important to recognize the nature of the lesion and not to confuse with the malignant tumors, mainly hepatocellular carcinoma and metastases of the liver.

The key point to differentiate it from hypervascular HCC is the absence of enhancement in arterial phase. Attention should be paid to the differentiation from hypovascular HCC. The following findings on MRI might be helpful: ① peripheral enhancement of lesions on the later phase; ② the presentation of septum and core, which has never been seen in HCC; ③ variable or irregular shape of the lesions, coalescence of several small lesions in one case; ④ most of the lesions were isointense on T₂WI, but more than 90% lesions of HCC were hyperintense on T₂WI[11]. MRI with mangafodipir trisodium might help distinguish inflammatory pseudotumor of the liver from hepatocellular carcinoma[12]. But peripheral ring-like enhancement may mimic the metastatic lesions. The history of primary malignant tumors and the absence of fibrotic septum or linear appearance within the mass and the most of lesions were hyperintense on T₂WI could help the differentiation.

In summary, in view of rare occurrence, few cases of inflammatory pseudotumor of the liver have been accurately diagnosed preoperatively in the past. Since MRI was put into clinical application and with experiences accumulated, the accuracy of diagnosing this disease has been greatly improved.

In conclusion, MRI is very imperative to reveal the features of the lesions, such as no early arterial enhancement, peripheral enhancement, septum and small nodular enhancement occurred in portal venous and delayed phases.