Investigation of intra-arterial chemotherapy infusion and embolization combined with abdominal chemotherapy for advanced gastric cancer

doi:10.3748/wjg.v4.iSuppl2.76

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Oct 15, 1998 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 15, 1998; 4(Suppl2): 76-76
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.76

Investigation of intra-arterial chemotherapy infusion and embolization combined with abdominal chemotherapy for advanced gastric cancer

Gui-Fang Li, Song-Bai Xie, Hai Sun, Xing-Hua Yang, Wan-Ju Liu, Qun Zhai, You-Xi Zhou, Zi-He Li, Guo-Min Zhang

Gui-Fang Li, Song-Bai Xie, Hai Sun, Xing-Hua Yang, Wan-Ju Liu, Qun Zhai, You-Xi Zhou, Zi-He Li, Guo-Min Zhang, Department of Oncology, the Air Force 454^th Hospital of PLA, Nanjing, 210002, Jiangsu Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Gui-Fang Li, Department of Oncology, the Air Force 454^th Hospital of PLA, Nanjing, 210002, Jiangsu Province, China

Received: July 14, 1998
Revised: August 19, 1998
Accepted: September 7, 1998
Published online: October 15, 1998

Abstract

AIM: To explore the feasibility and clinical benefit of intra -arterial chemotherapy infusion and embolization (GAI + GAE) combined with abdominal chemotherapy for advanced gastric cancer.

METHODS: Ninty-eight patients with advanced gastric cancer were randomized into three groups according to gender, age pathological classification, and clinical staging. Group A was treated with GAI + GAE combined with abdominal chemotherapy, Group B with abdominal chemotherapy, and Group C with intravenous chemotherapy. Group A was followed up for gastric mucosa change by gastroscopy.

RESULTS: The response rate for Group A, B and C was 71.88%，38.71% and 14.29%, respectively. The median survival duration for Group A, B and C was 16,10 and 8 mo, respectively. The response rate and median survival duration of Group A were significantly different from those of Group B (P < 0 .01) or Group C (P < 0.01), 5 patients in Group A had complete remission. The main side effects were gastrointestinal toxicity and inhibition of bone marrow. An injury to gastric mucosa was detected by gastroscopy within 2 wk after treatment in group A. Tissue repair took place by the 2^nd week. And normal gastric mucosa returned in 4 wk.

CONCLUSION: GAI + GAE combined with abdominal chemotherapy was an effective modality for advanced gastric cancer.

Key Words: Gastric neoplasms/drug therapy, Chemoembolization, therapeutic, Infusions, intra-arterial, Peritoneal cavity, Randomized controlled trials

Citation: Li GF, Xie SB, Sun H, Yang XH, Liu WJ, Zhai Q, Zhou YX, Li ZH, Zhang GM. Investigation of intra-arterial chemotherapy infusion and embolization combined with abdominal chemotherapy for advanced gastric cancer. World J Gastroenterol 1998; 4(Suppl2): 76-76
URL: https://www.wjgnet.com/1007-9327/full/v4/iSuppl2/76.htm
DOI: https://dx.doi.org/10.3748/wjg.v4.iSuppl2.76

Footnotes

E- Editor: Li RF