Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.76
Revised: August 19, 1998
Accepted: September 7, 1998
Published online: October 15, 1998
AIM: To explore the feasibility and clinical benefit of intra -arterial chemotherapy infusion and embolization (GAI + GAE) combined with abdominal chemotherapy for advanced gastric cancer.
METHODS: Ninty-eight patients with advanced gastric cancer were randomized into three groups according to gender, age pathological classification, and clinical staging. Group A was treated with GAI + GAE combined with abdominal chemotherapy, Group B with abdominal chemotherapy, and Group C with intravenous chemotherapy. Group A was followed up for gastric mucosa change by gastroscopy.
RESULTS: The response rate for Group A, B and C was 71.88%,38.71% and 14.29%, respectively. The median survival duration for Group A, B and C was 16,10 and 8 mo, respectively. The response rate and median survival duration of Group A were significantly different from those of Group B (P < 0 .01) or Group C (P < 0.01), 5 patients in Group A had complete remission. The main side effects were gastrointestinal toxicity and inhibition of bone marrow. An injury to gastric mucosa was detected by gastroscopy within 2 wk after treatment in group A. Tissue repair took place by the 2nd week. And normal gastric mucosa returned in 4 wk.
CONCLUSION: GAI + GAE combined with abdominal chemotherapy was an effective modality for advanced gastric cancer.