Experimental and clinical research of predicting chronic hepatitis progressing into serious hepatitis

doi:10.3748/wjg.v4.iSuppl2.110

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Oct 15, 1998 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 15, 1998; 4(Suppl2): 110-110
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.110

Experimental and clinical research of predicting chronic hepatitis progressing into serious hepatitis

Guo-Guang Sheng, Jian-Jun Zhang, Jian Liu, Ding-Bo Lu, Xie-Sheng Yian, Li-Wen Su, Ling Yang, An-Ping Ming

Guo-Guang Sheng, Jian-Jun Zhang, Jian Liu, Ding-Bo Lu, Xie-Sheng Yian, Li-Wen Su, Ling Yang, An-Ping Ming, Affiliated Hospital, Hubei College of TCM, Wuhan 430061, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Guo-Guang Sheng, Affiliated Hospital, Hubei College of TCM, Wuhan 430061, Hubei Province, China

Received: July 1, 1998
Revised: August 9, 1998
Accepted: August 31, 1998
Published online: October 15, 1998

Abstract

AIM: To seek early indicator of chronic hepatitis developing i nto serious hepatitis.

METHODS: Liver of rat damaged by D-Galactosamine was used as Dynamic observation of turmor necrosis factor (TNF), F-protein (FP), serum bilirubin (SB), prothrombin time (PT), and alanine aminotransferase (ALT) were performed. Pathological change of the liver tissue have been quantitatively analysed by the analysis instrument of image. The relationship between pathological changes of and laboratory markers were analysed using multilinear correlation, multivariate regression and stepwise logistic regression analysis by computer.

Clinical research based on patients of chronic active hepatitis B (All of the patients with middle degree or over chronic Hepatitis B according to the new standard). Apart from the above serum markers interleukin-2 receptor (SIL-2R) and gene mutation of HBV pre C have been detected. SAS software was used for analysis.

RESULTS: According to the result of clinical and experiment research, and combination with clinical practice. A predictive formula could be draw up for chronic Hepatitis B developing into sevious hepatitis. By dynamic observation and apphcation of different parameters into this formula, we can predict the tendency of chronic hepatitis developing into sevious hepatitis.

CONCLUSION: The predictive formula will be of reference value for clinicians to predict whether chronic hepatitis will develop into serious hepatitis.

Key Words: Hepatitis/Diagnosis, Hepatitis/Physiopathology, Liver/Pathology, Chronic diseases

Citation: Sheng GG, Zhang JJ, Liu J, Lu DB, Yian XS, Su LW, Yang L, Ming AP. Experimental and clinical research of predicting chronic hepatitis progressing into serious hepatitis. World J Gastroenterol 1998; 4(Suppl2): 110-110
URL: https://www.wjgnet.com/1007-9327/full/v4/iSuppl2/110.htm
DOI: https://dx.doi.org/10.3748/wjg.v4.iSuppl2.110

Footnotes

E- Editor: Li RF