Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.110
Revised: August 9, 1998
Accepted: August 31, 1998
Published online: October 15, 1998
AIM: To seek early indicator of chronic hepatitis developing i nto serious hepatitis.
METHODS: Liver of rat damaged by D-Galactosamine was used as Dynamic observation of turmor necrosis factor (TNF), F-protein (FP), serum bilirubin (SB), prothrombin time (PT), and alanine aminotransferase (ALT) were performed. Pathological change of the liver tissue have been quantitatively analysed by the analysis instrument of image. The relationship between pathological changes of and laboratory markers were analysed using multilinear correlation, multivariate regression and stepwise logistic regression analysis by computer.
Clinical research based on patients of chronic active hepatitis B (All of the patients with middle degree or over chronic Hepatitis B according to the new standard). Apart from the above serum markers interleukin-2 receptor (SIL-2R) and gene mutation of HBV pre C have been detected. SAS software was used for analysis.
RESULTS: According to the result of clinical and experiment research, and combination with clinical practice. A predictive formula could be draw up for chronic Hepatitis B developing into sevious hepatitis. By dynamic observation and apphcation of different parameters into this formula, we can predict the tendency of chronic hepatitis developing into sevious hepatitis.
CONCLUSION: The predictive formula will be of reference value for clinicians to predict whether chronic hepatitis will develop into serious hepatitis.