Analysis of the clinical effectiveness of the HCPT combination chemotherapy in treating 38 cases of late malignant tumour of digestive tract

Abstract

AIM: To study the effectiveness and toxic reaction of the HCPT combination chemotherapy in treating late tumour of digestive tract.

METHODS: In the combination chemotherapy plan of the carcinoma of esophagus stomach, large intestine, HCPT dose was 20 mg each time, twice each cycle, 21 d was one cycle, three cycles was one course of treatment, total dose was 120 mg. 8 mg of Shudan (on dansetron) is injected by intravenous 15 min before chemotherapy. 20 mg of Benadryl was injected by intramuscular after chemotherapy; increasing fluid infusion when PDD was used; detoxifying by CF when high dose MTX and 5-Fu were used at the same time urine was alkalizated.

RESULTS: 38 patients had been treated for one course of treatment, effective rate: carcinoma of esophagus was 44.4%, carcinoma of stomach 42.9%, carcinoma of large intestine 37.5%. Clinical observation showed: if HCPT is used rationally in combination chemotherapy of late tumor of digestive tract, we can obtain satisfactory effectiveness can be obtained, and also the toxic reaction of HCPT is mainly that hemogram decreases at II degree, and reaction of digestive tract is light.

CONCLUSION: HCPT's price is cheaper, it's effectiveness is exactly. It's toxic reaction is also light. Therefore, the plan of the HCPT combination chemotherapy has an important practical value in the chemotherapy of the late tumor of digestive tract.

Key Words: Esophageal neoplasms/drug therapy, Stomach neoplasms/drug therapy, Colonic neoplasms/drug therapy, Rectal neoplasms/drug therapy, Camptothecin/therapeutic use