Correction to "CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma"

Abstract

Correction to "CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. World J Gastroenterol 2017; 23: 2308-2317 [PMID: 28428710 DOI: 10.3748/wjg.v23.i13.2308]”. Due to the high number of images, the Tubulin bands intended for Figure 2D were incorrectly stored in the folder for Figure 3D, resulting in the wrong image being used for the Tubulin bands in Figure 3D.

Key Words: Correction; World Journal of Gastroenterology

Core Tip: This manuscript is to add a correction note to "CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. World J Gastroenterol 2017; 23: 2308-2317 [PMID: 28428710 DOI: 10.3748/wjg.v23.i13.2308]”.

CORRECTION

In this correction, we wish to address an error identified in our published manuscript titled "CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma" in the World Journal of Gastroenterology[1].

During figure preparation, the Tubulin bands intended for Figure 2D were inadvertently misplaced in the folder for Figure 3F, resulting in an incorrect image being used for the Tubulin bands in Figure 3F. This error arose solely from image misplacement and does not affect the scientific validity or conclusions of the paper. Additionally, Figure 3D and 3F derive from the same experimental batch (HMGB1 knockdown). For clarity, Figure 3D (Clone formation assay after HMGB1 knockdown) includes HMGB1 and Tubulin bands, which are also shown in Figure 3F (see Figure 1 in this correction). Similarly, Figure 2D and Figure 4A originate from the same experiment (LAMP-2a knockdown), in which the expression levels of p53, p21, HMGB1, and Tubulin proteins were simultaneously detected by Western blot. To more clearly present our findings, we separately display the relevant protein expression results in Figures 2D and 4A (Figure 2D: Changes in p53 and p21 protein levels after LAMP-2a knockdown; Figure 4A: Changes in HMGB1 protein levels after LAMP-2a knockdown).

Figure 1 Corrected Figure 3D and F. A: Corrected Figure 3D; B: Corrected Figure 3F.

We apologize for the error in our published article[1]. However, we believe that this correction ensures the accuracy and integrity of the paper.