Effects of tetrandrine and verapamil on fibroblastic growth and proliferation

doi:10.3748/wjg.v3.i2.68

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 1997; 3(2): 68-68
Published online Jun 15, 1997. doi: 10.3748/wjg.v3.i2.68

Effects of tetrandrine and verapamil on fibroblastic growth and proliferation

Xue-Song Liu, Ding-Guo Li, Han-Ming Lu, Qin-Fang Wu

Xue-Song Liu, Ding-Guo Li, Han-Ming Lu, Qin-Fang Wu, Research Laboratory of Digestive Diseases, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China

Author contributions: All authors contributed equally to the work.

Received: September 22, 1996
Revised: January 31, 1997
Accepted: March 1, 1997
Published online: June 15, 1997

Abstract

AIM: To investigate the effect of tetrandrine (Tet) and verapamil (Ver) on liver fibrosis by evaluating their effects on the growth and proliferation of fibroblasts.

METHODS: Flow cytometry and imaging analysis were used to study the effects of combined and individual treatment of Tet and Ver on fibroblastic proliferation in vitro. Untreated control cells were used for comparison.

RESULTS: Compared to untreated fibroblasts, those treated with both Tet and Ver showed higher percentages of cells in the G₁ and G₂+M phase in the cell cycle of 3T6 fibroblasts (P < 0.01) and markedly elevated protein content, while those treated with Tet only showed significantly lower intracellular RNA content (1.5-2.0 μg, P < 0.01) and those treated with Ver only showed lower intracellular DNA content (15-20 μg, P < 0.01).

CONCLUSION: The inhibitory action of Tet and Ver on fibroblastic growth and proliferation might be responsible for the antifibrotic effects of these medications in liver fibrosis.

Key Words: Tetrandrine/pharmacology, Verapamil/pharmacology, Fibroblasts/drug effects, Liver cirrhosis/drug therapy

Citation: Liu XS, Li DG, Lu HM, Wu QF. Effects of tetrandrine and verapamil on fibroblastic growth and proliferation. World J Gastroenterol 1997; 3(2): 68-68
URL: https://www.wjgnet.com/1007-9327/full/v3/i2/68.htm
DOI: https://dx.doi.org/10.3748/wjg.v3.i2.68

Footnotes

Original title: China National Journal of New Gastroenterology (1995-1997) renamed World Journal of Gastroenterology (1998-)

S- Editor: Filipodia L- Editor: Jennifer E- Editor: Liu WX