Opinion Review Open Access
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2019; 25(16): 1907-1912
Published online Apr 28, 2019. doi: 10.3748/wjg.v25.i16.1907
Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?
Sho Suzuki, Mitsuru Esaki, Chika Kusano, Hisatomo Ikehara, Takuji Gotoda
Sho Suzuki, Mitsuru Esaki, Chika Kusano, Hisatomo Ikehara, Takuji Gotoda, Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo 1018309, Japan
ORCID number: Sho Suzuki (0000-0003-4831-1409); Mitsuru Esaki (0000-0001-7353-2153); Chika Kusano (0000-0002-3789-4787); Hisatomo Ikehara (0000-0001-9239-7495); Takuji Gotoda (0000-0001-6904-6777).
Author contributions: All authors contributed equally to the conception and design of the study, literature review and analysis, drafting and critical revision and editing, and approval of the final version.
Conflict-of-interest statement: Gotoda T received honorarium from AstraZeneca K.K., Daiichi Sankyo Company Limited, EA Pharma Co., Ltd., and Takeda Pharmaceutical Company Limited.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sho Suzuki, MD, PhD, Doctor, Research Associate, Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 1-6 Kanda-Surugadai, Chiyoda-ku, Tokyo 1018309, Japan. suzuki.sho@nihon-u.ac.jp
Telephone: +81-3-32931711 Fax: +81-3-32931711
Received: February 6, 2019
Peer-review started: February 6, 2019
First decision: March 14, 2019
Revised: March 18, 2019
Accepted: March 24, 2019
Article in press: March 25, 2019
Published online: April 28, 2019

Abstract

Helicobacter pylori (H. pylori) antimicrobial resistance is an urgent, global issue. In 2017, the World Health Organization designated clarithromycin-resistant H. pylori as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of H. pylori infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment regimens provide acceptable H. pylori eradication rates, the regimens used should not contribute to future resistance of H. pylori to antimicrobials. Moreover, these regimens can promote resistance, due to prolonged therapy with multiple antibiotics. A new strategy that can eradicate H. pylori as well as reduce the antibiotics used is required to prevent future antimicrobial resistance in H. pylori. Dual-therapy with vonoprazan and amoxicillin could be a breakthrough for H. pylori eradication in an era of growing antimicrobial resistance. This regimen may provide a satisfactory eradication rate of H. pylori and also minimize antimicrobial resistance due to single antibiotic use and the strong inhibitory effect of vonoprazan on gastric acid secretion.

Key Words: Helicobacter pylori, Antibiotic resistance, Antimicrobial resistance, Dual therapy, Vonoprazan

Core tip: The increasing antimicrobial resistance of Helicobacter pylori (H. pylori) is an urgent, global issue. Although current H. pylori treatment regimens provide acceptable eradication rates, these regimens could also be improved to optimize antibiotic usage and prevent antimicrobial resistance because these regimens use multiple antibiotic agents and have a long treatment duration. Dual therapy consisting of vonoprazan and amoxicillin may be an alternative treatment regimen for H. pylori eradication in an era of growing antimicrobial resistance and may provide sufficient H. pylori eradication rates and may help prevent future antimicrobial resistance of H. pylori.



INTRODUCTION

Helicobacter pylori (H. pylori) infection, one of the most common bacterial infections, affects approximately 50% of the world’s population[1]. H. pylori infection is a major cause of gastritis, gastric and duodenal ulcers, mucosal associated lymphoid tissue, and gastric cancer[2]. H. pylori eradication treatment has been proven to improve gastric inflammation, promote ulcer healing, and reduce the incidence of gastric cancer[3,4]. Furthermore, a “test-and-treat” approach is advocated for detecting and eradicating H. pylori in patients with dyspeptic symptoms but low gastric cancer risk[5].

H. pylori eradication treatment is becoming more challenging due to increasing antimicrobial resistance. Previously, a 7-d standard triple therapy consisting of a proton pump inhibitor (PPI), amoxicillin (AMPC), and clarithromycin (CAM) was recommended for eradicating H. pylori[6]. However, there has been a significant reduction in the eradication rate achieved with this regimen due to the increase in antimicrobial resistance of H. pylori. Resistance of H. pylori has reached alarming levels worldwide, which greatly affects the efficacy of treatment. The World Health Organization (WHO) recently published its first ever list of antimicrobial resistant “priority pathogens,” which is a catalogue of 12 families of bacteria posing the greatest threat to human health. They indicated three priority statuses-critical, high, and medium-with CAM-resistant H. pylori being categorized as a high priority bacterium in the same tier as vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus. Furthermore, resistance to metronidazole (MNZ) and fluoroquinolones, which are mainly used as rescue therapies[7], has also increased more recently to over 15% in many regions of the world[8,9]. Thus, the mere avoidance of CAM in H. pylori eradication treatment is not enough to prevent and decrease antimicrobial resistance of H. pylori. Actually, a recent study of the influence of a government-introduced, restrictive antibiotic policy on the rates of resistance of H. pylori in Taiwan indicated an increase in levofloxacin resistance since the restriction of macrolides[10].

RECENT STANDARD H. PYLORI THERAPIES AND THE CONCERN FOR ANTIMICROBIAL RESISTANCE

Treatment regimens are expected to overcome the increasing prevalence of resistant strains of H. pylori and achieve a > 90% eradication rate. The eradication rates for first-line H. pylori treatment regimens published in meta-analysis and in a study of eradication rates of vonoprazan-based dual therapy are shown in Table 1. Recently, bismuth-containing quadruple therapy (BQT) or non-bismuth concomitant quadruple therapy (CQT) has been recommended by international guidelines as a first-line treatment for H. pylori in areas of high CAM and/or MNZ resistance[5,11,12]. Both BQT and CQT contain PPI and two to three kinds of antibiotic agents including AMPC, CAM, MNZ, nitroimidazole, and tetracycline with longer treatment durations of 10-14 d. It is reported that acceptable eradication rates of > 90% have been obtained by both regimens. Although BQT and CQT provide acceptable H. pylori eradication rates, they have many limitations, such as a complicated protocol, high cost, adverse side effects, and poor patient compliance due to multiple drug combinations[13]. Furthermore, these regimens must not contribute to antimicrobial resistance of H. pylori; moreover, they may promote future resistance because of the use of multiple antibiotics for a long duration. The alarming global rates of H. pylori resistance in treatment-naïve patients can be correlated with the increasing and uncontrolled use of antibiotics that are commonly used in H. pylori empirical therapy and in therapy for other common infections in the general population[14]. Increased antibiotic usage worldwide has led to antimicrobial resistance among many bacteria, including H. pylori, resulting in falling success rates of H. pylori eradication treatment. These regimens could also be improved to optimize antibiotic usage to prevent antimicrobial resistance.

Table 1 Treatment regimens for first-line Helicobacter pylori therapies and its successful eradication rates.
RegimensPPIAntibioticsTreatment durationEradication rates
Bismuth quadruple therapyEsomeprazole 20-40 mg bid; Omeprazole 20-40 mg bidTC 125 mg qid; MNZ 125 mg qid10 d90%[35]
Concomitant quadruple therapyEsomeprazole 20-40 mg bid; Lansoprazole 30 mg bid; Omeprazole 20-40 mg bid; Pantoprazole 40 mg bid; Rabeprazole 10-20 mg bidAMPC 750 mg-1 g bid; CAM 200-500 mg bid; MNZ or TNZ 250-500 mg bid5-14 d83%[36]
Standard triple therapyEsomeprazole 40 mg bid; Lansoprazole 30 mg bid; Pantoprazole 40 mg bid; Rabeprazole 10-20 mg bidAMPC 500 mg-1 g bid; CAM 200-500 mg bid7 d[37]; 14 d[38]73%[37]; 81%[38]
High dose dual therapyEsomeprazole 20 mg qid; Omeprazole 40 mg qid; Rabeprazole 10-20 mg qidAMPC 750 mg qid14 d86%[39]
Vonoprazan based triple therapyvonoprazan 20 mg bidAMPC 750 mg bid; CAM 200-400 mg bid7 d88%[37]
Vonoprazan based dual therapyvonoprazan 20 mg bidAMPC 500 mg tid7 d94%[32]

WHO launched the Global Action Plan on Antimicrobial Resistance to ensure, for as long as possible, the continuity of the ability to treat and prevent infectious diseases with effective and safe medicines that are quality-assured, used in a responsible way, and accessible to all who need them. Five objectives are listed in this document and the fourth objective is “to optimize the use of antimicrobial medicines in human and animal health.” They state that “extent of reduction in global human consumption of antibiotics, the consumption of antibiotics used in food production, and the use of medical and veterinary antimicrobial agents for applications other than human and animal health” are a potential measure of effectiveness for optimizing the use of antimicrobial medicines in human and animal health. Thus, the increase in resistance to CAM and the existence of multi-resistance to various families of antibiotics must be addressed by the appropriate use of antibiotics in H. pylori treatment. Antimicrobial susceptibility testing is the best way to optimize and reduce antibiotics for H. pylori eradication treatment as well as treating other common infections. Antimicrobial susceptibility testing is recommended to enable tailoring of the eradication therapy presented in the international guidelines[5], to ensure successful eradication[15,16]. However, antimicrobial susceptibility testing is not a routine clinical practice due to the invasiveness of the endoscopy procedure, time consuming nature, the availability of laboratory culture facilities, and cost considerations[17]; non-invasive methods are being developed[18].

PROSPECTS OF NEW STRATEGIES FOR ENSURING ERADICATION OF H. PYLORI AND PREVENTION OF ANTIMICROBIAL RESISTANCE

A new strategy that could provide sufficient eradication rates as well as decrease the amount of antibiotics is essential for the prevention of future antimicrobial resistance of H. pylori. Dual therapy with AMPC and PPI could be a possible solution because this regimen is a single-antibiotic therapy, and it is well known that H. pylori is hardly resistant to AMPC. Currently, the resistance rates of H. pylori to AMPC remain low (0%-5%)[19,20]. A dual therapy comprising a PPI and AMPC was first introduced in the 1990s as a first-line regimen for H. pylori infection[21]. As dual therapy of PPI and AMPC administered at standard doses did not achieve satisfactory treatment outcomes[22,23], it was subsequently used as a salvage treatment. Recently, Yang et al[24] reported that a high-dose dual therapy consisting of AMPC and rabeprazole achieved an eradication rate of 95.3% in first-line therapy, and 89.3% in rescue therapy. However, this method needed a high frequency and a high dose of AMPC and PPI for a longer duration (e.g., rabeprazole 20 mg and amoxicillin 750 mg 4 times/d for 14 d) to attain an acceptable eradication rate of > 90%, which led to high cost, adverse side effects, and poor patient compliance.

One interesting possibility is to substitute conventional PPIs with vonoprazan for use in dual therapies. Vonoprazan-based dual therapy could be an alternative treatment regimen for H. pylori eradication, which could provide sufficient eradication rates of H. pylori and minimize antimicrobial resistance. The key to a successful dual therapy regimen is a PPI-generated neutral environment suitable for bacterial growth; this causes dormant H. pylori to enter a replicative state and makes H. pylori sensitive to AMPC. Vonoprazan is a novel potassium competitive acid blocker that has a strong and long-lasting effect on inhibition of acid secretion[25,26]. In addition, the pharmacokinetic features of vonoprazan are not affected by CYP2C19 polymorphisms[27,28]. It is reported that seven days of standard triple therapy containing vonoprazan provided approximately 90% eradication rate attributable to effective gastric acid inhibition and the maintenance of a high gastric pH, and had a high safety profile irrespective of age[29-31]. To the best of our knowledge, there is only one study on vonoprazan and AMPC dual therapy; this study showed that a regimen consisting of vonoprazan 20 mg twice per day and AMPC 500 mg three times/d for seven days provided sufficient eradication rates of 93.8% of H. pylori infection[32]. This seven-day, vonoprazan-based dual therapy may have additional advantages in terms of treatment compliance and medical costs as fewer agents are used and the duration of the therapy is shorter than that of other recent standard treatment regimens (such as BQT, CQT, and sequential therapies). Vonoprazan-based dual therapy may be a recent breakthrough that could ensure a satisfactory eradication rate with the use of minimum antibiotic agents and a short treatment duration. Furthermore, reducing antibiotics may prevent changes and dysbiosis in gut microbiota composition, which are caused by antibiotics used in H. pylori eradication therapy[33]. Although vonoprazan-based dual therapy potentially has these advantages, it also has several limitations for implementation in clinical setting. First, vonoprazan is available in a few countries. Vonoprazan was developed and launched in Japan in 2015. However, it is now available in several Asian countries including Philippine, Singapore, and Thailand, and has been approved in other regions, including South America (countries such as Argentina and Peru). Thus, vonoprazan may become available and can be used for H. pylori eradication therapy worldwide in the near future. Second, this regimen cannot be used in patients with penicillin allergy and thus antimicrobial susceptibility testing should be performed in these patients to optimize H. pylori eradication therapy. Although the conventional antimicrobial susceptibility testing is invasive due to the need of endoscopy and biopsy as mentioned above, a non-invasive molecular test using fecal sample has also been recently developed[34]. This method involves the isolation of H. pylori DNA from stool and detection of point mutations conferring antimicrobial resistance by polymerase chain reaction. This method should be considered for testing antimicrobial susceptibility in patients with penicillin allergy before H. pylori eradication therapy. Finally, there are few data and studies regarding this regimen. Further studies should be conducted to prove its efficacy and safety profile.

CONCLUSION

In this review, we outline the urgent, global issue of H. pylori antimicrobial resistance and propose our prospects of approach for the issue. H. pylori treatment is becoming more challenging because of the increasing antimicrobial resistance to not only CAM but also to MNZ and fluoroquinolones. Thus, there is a need to develop new H. pylori eradication therapies that provide an acceptable eradication rate, better safety and tolerability profile, and good patient compliance, while preventing the increase in H. pylori antimicrobial resistance. One interesting possibility is the use of vonoprazan in dual therapy with AMPC, which has been shown to have over a 90% eradication rate. Large scale, randomized control trials should be conducted to verify and establish this finding in the future.

Footnotes

Manuscript source: Invited manuscript

Specialty type: Gastroenterology and hepatology

Country of origin: Japan

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P-Reviewer: Bang CS, Ierardi E S-Editor: Ma RY L-Editor: A E-Editor: Song H

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