Published online Apr 28, 2019. doi: 10.3748/wjg.v25.i16.1907
Peer-review started: February 6, 2019
First decision: March 14, 2019
Revised: March 18, 2019
Accepted: March 24, 2019
Article in press: March 25, 2019
Published online: April 28, 2019
Core tip: The increasing antimicrobial resistance of Helicobacter pylori (H. pylori) is an urgent, global issue. Although current H. pylori treatment regimens provide acceptable eradication rates, these regimens could also be improved to optimize antibiotic usage and prevent antimicrobial resistance because these regimens use multiple antibiotic agents and have a long treatment duration. Dual therapy consisting of vonoprazan and amoxicillin may be an alternative treatment regimen for H. pylori eradication in an era of growing antimicrobial resistance and may provide sufficient H. pylori eradication rates and may help prevent future antimicrobial resistance of H. pylori.