Copyright ©The Author(s) 2017.
World J Gastroenterol. Jun 14, 2017; 23(22): 3978-3998
Published online Jun 14, 2017. doi: 10.3748/wjg.v23.i22.3978
Table 6 Loss of heterozygosity and microsatellite instability studies reported in gallbladder cancer
Studied reported in respective populationLOH/MSIRef.
ChileanLOH reported in : 3p, 6q, 7q, 8p, 9p, 9q, 11q, 12q, 17p, 18q, 19p, 22q, and Xq[57]
JapanLOH reported in : 2p, 4p, 4q, 8q,9q, 10p,14p,14q,16p, 19p, 21p and Xp [Maximum deletion- 2p24, 14q22 and 21q22][68]
Chilean, Japanp53, 9p.8p, DCC, KRAS, p16, 16q24, 3p,9q, 22q and p161NK4[54,66,109,112,185]
Chile, JapanMSI reported (20%-33%)[187,188]
IndiaE-cadherin (CDH1) 2p, 2q, 6q, 7q,17p[189]
IndiaFragile histidine triad (FHIT) MSI-H 17.5% LOH :27.5%[190]
JapanHigh incidences of LOH at 1p36 (19/36:53%), 9p21 (12/32:38%), 13q14 (20/36: 56%), 16q24 (31/54: 61%), and 17p13 (15/36: 42%)[191]
ChileFHIT gene locus (3p14.2)[109]
IndiaLOH at 8 loci, that is 3p12, 3p14.2, 5q21, 9p21, 9q, 13q, 17p13, and 18q for tumor suppressor genes (DUTT1, FHIT, APC, p16, FCMD, RB1, p53, and DCC genes)[192]
Indiagenomic instability at 2p, 2q, 6q, 7q, and 17p loci[189]
ChileDUTT1 (3p12), FHIT (3p14.2), BLU, RASSF1A, SEMA3B and hMLH1 (3p21.3)[193]