Copyright ©The Author(s) 2017.
World J Gastroenterol. Jun 14, 2017; 23(22): 3978-3998
Published online Jun 14, 2017. doi: 10.3748/wjg.v23.i22.3978
Table 5 Summary of single gene expression studied reported in gallbladder cancer
Studied single genesExpression patternStudied populationRef.
TP53Expression (20%-70%)India, Slovenia, Greece, Taiwan, Japan, Chile[75,84-86,102-106]
p16OverexpressionSouth Korea[107]
FHITExpression loss (45%-75%)Japan, Chile[108,109]
ERBB2Overexpression (25%-64%)India, Japan, China, South Korea[66,103,110,111]
Expressed in 9.4%cases of well differentiated and stage II to stage IV tumorsIndia[90]
RB20% cases allelic lossJapan[54,112]
4%-14%- loss of expression
CDKN1AReduced expression 49% casesJapan[113]
Cyclin D1, Cyclin EOverexpression (41%-49%)Japan[114,115]
COX2Over-expressedSlovenia, Japan, Chile[104,116,117]
CKITExpression 45%Japan[119]
Chemokine (C-X-C motif) ligand 12Increased expressionSouth Korea[121]
CXCR4, CXCR7Increased expressionChina[122]
hedgehog pathway components (Shh, Ptch1 and Gli1)Shh: 81.7% of cases expressedChina[123]
Ptch1: 75.3% of cases
Gli1: 70.0% of cases
CD56, CD99Altered expressionSouth Korea[124]
CD97, CD55CD97: 69.6% of cases expressedChina[125]
CD55: 65.2% of cases
HMGA2 and CD9HMGA2 positive expressionChina[126]
CD9 negative expression
cholecystokinin type-A44.1% of cases expressedIndia[127]
vascular endothelial growth factor-A53.6% of cases expressedChina[128]
VEGF-C, VEGF-DVEGF-C: 64.0% of casesChina[129]
VEGF-D: 62.0% of cases
Tumor endothelial marker 8 proteinIncreased expressionIndia[130]
L1 cell adhesion moleculeIncreased expressionSouth Korea[131]
Tissue factor pathway inhibitor-2Down-regulatedChina[132]
HIF-1αIncreased expressionChina[133]
VHLReduces expression
ERCC1(excision repair cross-complementing 1)High expression in best differentiated tumorsChile[134]
NF-E2-related factor 2 (Nrf2)Increased expressionChina[135]
CD34 , CA15-3Highly expressed in stroma and in epitheliumItaly[136]
Cdx2Aberrant expressionJapan[138]
TLR4Expressed in glandular and luminal epitheliumChina[139]
MiRNALoss of Dicer and Drosha expressionChina[140]
Inducible Nitric Oxide Synthase iNOSExpressedChina[141]
Prostate stem cell antigen (PSCA)Down-regulatedJapan, China[142]
hTERT/TelomeraseExpressed in 56.66% casesIndia[144]
Aquaporins (AQPs)Positive expressionJapan[145]
Ornithine decarboxylase (ODC) and glutamate decarboxylase 65 (GAD65)OverexpressionChina[146]
Alpha-methylacyl coenzyme A (racemase) AMACROverexpressionTaiwan[147]
Sonic Hh (Shh)Elevated expressionJapan[148]
TGF-β induced miR-182OverexpressionChina[149]
TMPRSS4Higher expressionChina[151]
zinc finger X-chromosomal proteinSuppressedChina[152]
multidrug resistance-associated protein 2 (MRP2)OverexpressionSouth Korea[153]
p27, P21p21 (75% cases) and p27 (25% cases)Jordan[157]
Thymidylate synthase (TS)Low expressionJapan[158]
CD146Elevated expressionChina[159]
AEG-1Highly expressed (63.4%)China[160]
CCKARExpression increased (76.6%)India[127]
Nemo-like kinase (NLK)Overexpression of NLKChina[161]
C-erbB2Overexpression (9.4%)India[90]
Phospho-mTOR expressionPositive expression (64.1%)Chile[162]
human telomerase reverse transcriptase (hTERT)Expression increasedIndia[163]
Phosphoglycerate kinase 1 (PGK1)Decreased expression (54.7%)China[164]
Notch 1 and Notch 3Positive expressionChina[165]
CCK-ADecreased expressionIndia[166]
3-phosphoinositide-dependent protein kinase 1 (PDK1)Positively expressedChina[167]
Zinc finger X-chromosomal protein (ZFX)OverexpressionChina[151]
miR-138Over expressionChina[168]
HSP gp96Expression (90.7%)China[169]
Long non-coding RNA-LETOverexpressionChina[170]
Survivinhigher expression (2.9- fold)India[171]
Long non-coding RNA CCAT1OverexpressedChina[172]
TEM8Expression increasedIndia[130]
Fhit,MIh1, P53Reduced expression of Fhit and Mlh1 protein and Overexpression of P53Japan[108]
NDRG2, CD24NDRG2 down-regulation, CD24 up-regulationChina[173]
BCL6, p19(ARF)BCL6 overexpression , p19 (ARF) Low ExpressionTaiwan[175]
VEGF-AHigh expression of VEGF-AChile[176]
MALAT1Upregulation of MALAT1China[177]
miR-182Upregulation of miR-182China[149]
miR-155High expression level of miR-155Japan[155]
p53, S100A4, p27, p16, RB, Smad4, FHIT, E-cadherin and PMLp53 and S100A4 overexpressed,South Korea[178]
Loss of p27, p16, RB, Smad4, FHIT, E-cadherin and PML expression
PEG10, TSG101PEG10 and TSG101 overexpressedChina[179]
CK7, CK20CK7 (69.05%), CK20 (28.57%) expressedGreece[180]