Copyright ©The Author(s) 2017.
World J Gastroenterol. Jun 14, 2017; 23(22): 3978-3998
Published online Jun 14, 2017. doi: 10.3748/wjg.v23.i22.3978
Table 4 Summary of global gene expression studies in gallbladder cancer
Biological sample usedPlatform/studies key findingsRef.
17 gallbladder tissue specimens (6 advanced GBC , 6 early GBC cancers and 5 normal controlOligonucleotide Microarray platform[97]
Unregulated genes: 2270
Downregulated genes: 2412
5-Normal biliary epithelial scrapings, 11- surgically resected biliary carcinomas, 9-biliary cancer cell linesOligonucleotide Microarray platform[98]
Unregulated genes : 282 genes
Downregulated genes: 513
37 biliary tract carcinomascDNA array platform[99]
(15 bile duct, 11 gallbladder, 11 of ampulla of Vater)118 genes were identified with a prognostic value
12 advanced gallbladder carcinoma tissue 3 samples of normal control gallbladder epitheliumOligonucleotide Array platform[100]
Upregulated: (TOPO II-alpha, cyclin B2, CDC28, ubiquitin-conjugating enzyme E2C), and one metabolism-related: (gamma-glutamyl hydrolase)[101]
34 biliary tract cancers includingOligonucleotide Array platform
13 intrahepatic (IHC), 12extrahepatic (EHC), 9 (GBC)1281 genes with deregulated expression pattern