Copyright ©The Author(s) 2015.
World J Gastroenterol. Apr 7, 2015; 21(13): 3801-3812
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3801
Table 2 Differences between intestinal Behçet’s disease and Crohn’s disease[39,40,48,49,52,54]
Crohn’s diseaseIntestinal BD
Extra-intestinal manifestationsIritis, episcleritis more specificOral and genital ulcers more common, papulopustular lesions, neurologic and arterial manifestations
Perianal disease (fistula, fissures)CommonRare
Strictures, fistula, abscessCommon, characteristic of disease processLess common but possible
Serologic markersAnti-saccharomyces cerevisiae antibody (Prevalence: 41%-76%)IgM anti-α-enolase antibody (Prevalence: 67.5%)
Endoscopic featuresIrregular, longitudinal ulcers with cobblestone appearance, may have aphthous lesions Segmental or diffuse involvementRound or oval shaped, punched-out lesions with discrete margins, > 1 cm, Focal distribution, < 5 ulcers. No aphthous lesions
Pathognomonic lesions on histopathologyNon-caseating epithelioid granulomaNon-specific neutrophilic or lymphocytic phlebitis with or without aortitis