Copyright ©The Author(s) 2015.
World J Gastroenterol. Mar 21, 2015; 21(11): 3206-3213
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3206
Table 1 CD9 associated with partner proteins
Partner proteinFunctionRef.
EWI-2Modulates integrin-dependent cell motility, morphology and/or spreading[5-6,8,44,45,50]
EWI-FFunctions unknown[5-6,8,46,47]
Integrin β1CD9 modulates integrin-dependent cell morphology, cell migration, signaling and adhesion strengthening[5,11]
Other tetraspanins (e.g., CD81, CD151)Form TEMs[7,8]
Claudin-1CD9 stabilizes expression of non-junctional Claudin-1[10]
EGFRCD9 enhances the internalization of EGFR and reduces EGF-EGFR-induced signals[11]
HB-EGFCD9 upregulates both diphtheria toxin binding and mitogenic functions of HB-EGF[23,24]
PKC isoformsContribute to signaling and tumor-suppressor functions[29]
Type II PI4KContribute to signaling and tumor-suppressor functions[30]